Understanding the impact of childhood tuberculous meningitis on health outcomes.
Official title: Interdisciplinary and multi-level approach to estimate the disease burden and outcomes of childhood tuberculous meningitis.
Funded at Stellenbosch University · NIH-10763370 · Data updated 2026-11-12
This study is looking at how childhood tuberculous meningitis affects kids' health, especially in countries with fewer resources, to help create better care and support for those who are sick.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stellenbosch University NIH-funded |
| Lab location | 1 site (Stellenbosch, SOUTH AFRICA) |
| Project start | February 5, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $113,400 |
| NIH project number | 5K43TW011006-05 |
| Project ID | NIH-10763370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 21 years old who are diagnosed with or at risk for tuberculous meningitis.
✕Less likely to help
Patients who do not have tuberculous meningitis or are over the age of 21 may not benefit from this research.
What this research studies
This research investigates the disease burden and health outcomes associated with childhood tuberculous meningitis, particularly in low and middle-income countries. It employs interdisciplinary methods, including disease estimation modeling and spatial analytics, to gather and analyze data on pediatric tuberculosis. The goal is to translate findings into effective health policies and practices that can improve care for affected children. The research is led by Dr. Karen du Preez at Stellenbosch University, supported by a team of experts in pediatric TB.
Why it matters
Potential benefit: If successful, this research could lead to improved health care policies and practices for children suffering from tuberculous meningitis.
How similar studies have gone: Previous research has shown success in improving pediatric TB outcomes through similar interdisciplinary approaches, indicating potential for impactful findings in this area.
Where this research is happening
-
Stellenbosch University
Stellenbosch, South Africa Active
Researchers
- Principal investigator: Du Preez, Karen — Stellenbosch University
- Study coordinator: Du Preez, Karen
Related research
Other NIH-funded projects on the same topics.
-
Personalized Immunomodulatory Therapy for HIV-related Cryptococcal Meningitis
A patient-focused study investigates a personalized treatment approach to improve outcomes for people with HIV who develop cryptococcal meningitis.
-
Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis
A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.
-
TB meningitis diagnostic test compare and cost study in sub-Saharan Africa
Researchers are testing a new CSF urine-based test (SILVAMP TB LAM) to improve diagnosis of TB meningitis in people with HIV, to help speed treatment and reduce death in Sub-Saharan Africa.
-
Minimally Invasive Sampling to Improve HIV-Associated M meningitis Diagnosis in Africa
A research study is testing easier, less invasive ways to diagnose meningitis in people living with HIV, with a focus on making diagnosis faster and more accurate in Africa and the US.
-
Understanding brain injury in kids with tuberculous meningitis (iThemba)
A study in children with TB meningitis in South Africa will look at how inflammation and blood-clotting factors relate to brain injury and infarcts.
-
Serological clues to survival in HIV-related cryptococcal meningitis
This grant looks for antibody signals in the blood that could predict who survives cryptococcal meningitis in people with HIV.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.