Improving survival in patients with cryptococcal meningitis and altered mental status
Official title: Targeting Neuropathogenesis of Altered Mental Status to Improve Survival in Cryptococcal Meningitis
Funded at University of Minnesota · NIH-10873789 · Data updated 2026-11-12
This study is looking at how cryptococcal meningitis affects the brain in people with HIV/AIDS, hoping to find out what changes happen that might make things worse, so we can improve treatments and help patients live better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 16, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $201,420 |
| NIH project number | 5K23NS122601-04 |
| Project ID | NIH-10873789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are diagnosed with cryptococcal meningitis and have a history of HIV/AIDS.
✕Less likely to help
Patients with cryptococcal meningitis who are under 21 years old or do not have a history of HIV/AIDS may not benefit from this research.
What this research studies
This research investigates the neurological abnormalities associated with altered mental status in patients diagnosed with cryptococcal meningitis, particularly in those with HIV/AIDS. The study aims to identify the specific neurological changes that lead to increased mortality in these patients. By employing advanced neurologic techniques and laboratory analyses, the research seeks to enhance understanding of the condition and improve management practices. Patients may benefit from improved treatment protocols based on the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to better survival rates and treatment strategies for patients suffering from cryptococcal meningitis.
How similar studies have gone: Previous research has shown significant associations between altered mental status and mortality in cryptococcal meningitis, indicating that this area of investigation is both relevant and necessary.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Abassi, Mahsa — University of Minnesota
- Study coordinator: Abassi, Mahsa
Related research
Other NIH-funded projects on the same topics.
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Personalized Immunomodulatory Therapy for HIV-related Cryptococcal Meningitis
A patient-focused study investigates a personalized treatment approach to improve outcomes for people with HIV who develop cryptococcal meningitis.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.