Investigating immune responses in TB meningitis among HIV-infected individuals
TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory Therapies
This study is looking at how the immune system responds in people with tuberculous meningitis who also have HIV, to find out what helps them do better or worse, with the hope of improving diagnosis and treatment options for patients in Uganda.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10888216 on NIH RePORTER |
What this research studies
This research focuses on understanding the immune responses in patients with tuberculous meningitis (TBM) who are also living with HIV. It aims to identify the specific immune signatures that are associated with better or worse outcomes in these patients. By utilizing advanced diagnostic techniques, the study seeks to improve the detection of TBM and explore potential immunomodulatory therapies that could enhance treatment effectiveness. The research team, experienced in clinical and translational studies, will conduct this work primarily in Uganda, where the burden of TBM is significant.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are living with HIV and have been diagnosed with or are suspected to have tuberculous meningitis.
Not a fit: Patients who are not living with HIV or do not have tuberculous meningitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients suffering from TB meningitis, particularly those with HIV.
How similar studies have performed: Other research has shown promise in understanding immune responses in TBM, but this specific approach focusing on HIV-infected individuals is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Boulware, David R — University of Minnesota
- Study coordinator: Boulware, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.