Condition

Bacterial Infections clinical trials and research

• 17Clinical trials
• 29NIH research projects
• 21Countries

Newest Bacterial Infections clinical trials

All recruiting trials (17)

• CTX-187 first-in-human test in healthy people and people with chronic bronchiectasis and Pseudomonas infection

  This study tests CTX-187 to see if it is safe and tolerable when given as IV infusions to healthy adults and adults with chronic bronchiectasis and Pseudomonas aeruginosa infection.

  Recruiting Phase 1 Centauri Therapeutics Limited · Groningen · NCT07708116

• Personalized beta-lactam dosing in cirrhosis patients with bacterial infections

  This study tests whether tailoring beta-lactam dosing based on patient liver disease and drug levels can help people with cirrhosis and bacterial infections.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07612163

• Vaginitis Diagnostic Algorithm Pilot Using Nanopath and Other Tests

  This study tests a new Nanopath vaginal test to see if it correctly detects vaginitis-causing pathogens in up to 1,000 people with vaginitis symptoms.

  Recruiting at 2 sites Nanopath, Inc · North Miami, Florida and 1 other locations · NCT07607470

• Testing single and multiple IV doses of JKN2501 in healthy Chinese adults

  This test gives single and multiple intravenous doses of JKN2501 to healthy Chinese adults to see if it's safe and how the body processes it.

  Recruiting Phase 1 Joincare Pharmaceutical Group Industry Co., Ltd · Changsha, Hunan · NCT07207291

• Tracking acute treatment and long-term outcomes in children with meningitis

  This registry will collect care and outcome information to see how current treatments affect short- and long-term outcomes in children under 18 with suspected meningitis in Brazil.

  Recruiting Hospital Israelita Albert Einstein · São Paulo, São Paulo · NCT07062445

• Single antibiotic versus two antibiotics for Pseudomonas bone infection

  This study will test whether one antibiotic works as well as two for adults with bone infections caused by Pseudomonas aeruginosa.

  Recruiting Centre Hospitalier de Saint-Denis · Saint-Denis, France · NCT07056881

• Improving health and quality of life for patients recovering from infective endocarditis through cardiac rehabilitation

  This study is testing if joining a cardiac rehabilitation program can help people recovering from infective endocarditis feel healthier and improve their quality of life.

  Recruiting Region Halland · Halmstad, Halland County · NCT06704048

• Tracking antibiotic resistance in patients with cirrhosis and infections

  This study looks at how common antibiotic resistance is in patients with cirrhosis who get infections to help create better treatment guidelines for doctors in Latin America.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires F.D. · NCT06634940

• AI program predicts bacterial species from urine Gram stain specimens

  This study is testing a new AI program that helps doctors quickly and accurately identify bacteria in urine samples to make diagnosing infections easier.

  Recruiting GramEye · Shinjuku-Ku, Tokyo · NCT06554145

• Using AI to identify bacterial species from microscope images

  This study is testing if artificial intelligence can help doctors quickly and accurately identify certain bacteria from microscope images in patients getting AFB smear tests.

  Recruiting GramEye · Suita, Osaka · NCT06519032

• Evaluating AI for Gram Staining Analysis

  This study is testing a new artificial intelligence tool to see if it can help doctors more accurately identify bacterial infections from lab samples.

  Recruiting GramEye · Suita, Osaka · NCT06377592

• Comparing antibiotic strategies for infected patients with cirrhosis

  This study tests whether using regular antibiotics or those chosen based on infection data works better for adults with cirrhosis and bacterial infections.

  Recruiting Phase 4 Institut d'Investigacions Biomèdiques August Pi i Sunyer · Barcelona · NCT05783661

• Evaluating XEMBIFY® with standard treatment to prevent infections in patients with certain blood cancers

  This study is testing if adding XEMBIFY® to standard treatment can help prevent serious infections in adults with certain blood cancers.

  Recruiting at 56 sites Phase 3 Grifols Therapeutics LLC · Bullhead City, Arizona and 61 other locations · NCT05645107

• Using procalcitonin levels to guide antibiotic treatment in critically ill children

  This study is testing if using procalcitonin levels can help doctors safely shorten antibiotic treatment for critically ill children with bacterial infections.

  Recruiting at 4 sites University Hospital, Toulouse · Amiens and 7 other locations · NCT05350813

• Emergency PanorOmics Wide Association for Respiratory Infections

  This study is trying to quickly identify different respiratory infections in adults visiting the emergency room to help develop better tests and treatments for these illnesses.

  Recruiting The University of Hong Kong · Hong Kong · NCT05336851

• Imaging bacterial infections using a radioactive tracer

  This study is testing a new radioactive tracer to see if it can help doctors find and understand bacterial infections in people who already have them.

  Recruiting Phase 1 University of Pennsylvania · Philadelphia, Pennsylvania · NCT04263792

• Using fosfomycin to treat severely infected patients

  This study is testing if an intravenous antibiotic called fosfomycin can safely help people with serious infections like osteomyelitis and bacterial meningitis feel better.

  Recruiting at 45 sites Infectopharm Arzneimittel GmbH · Hall in Tirol and 49 other locations · NCT02979951

NIH-funded research (29)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Host-Directed Orynotide for MDR Gram-Negative Infections

  A new drug candidate called Orynotide MTD12813 is being developed to treat serious drug-resistant infections caused by bacteria like Acinetobacter and Enterobacteriaceae.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11385419

• Genomic-informed, low-cost, portable test to rapidly identify drug-resistant bacterial infections

  A portable, affordable test called BADLOCK could quickly identify bacteria and resistance genes from blood samples to help treat drug-resistant infections.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11378811

• Novel BMX antibiotics for tough Gram-negative infections

  A new class of BMX antibiotics is being developed to fight hard-to-treat Gram-negative infections like Acinetobacter baumannii in patients.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11375081

• Center to speed up antibacterial drugs for hard-to-treat infections

  A national center at Hackensack University Medical Center aims to speed up the development of new antibiotics to fight high-threat, drug-resistant bacterial infections.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11372866

• Center accelerating antibiotic development for high-threat bacterial infections

  A research center in academia–industry collaboration is speeding up the development of new antibiotics to fight highly resistant bacteria so patients have better treatment options.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11372864

• PACC1 in the body’s defense against bacterial infections and sepsis

  A study exploring how a protein called PACC1 helps immune cells fight bacteria and prevent sepsis, with potential benefits for people at risk of severe infections.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11368037

• Comparative safety of antibiotics for common infections in pregnancy

  This project looks at which antibiotics are safest for babies when used to treat common infections in pregnant women.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11336396

• High-affinity antibodies against bacterial surface sugars to combat deadly infections

  A patient-facing opportunity to explore new antibody-based therapies that target tough, antibiotic-resistant bacteria by recognizing their surface sugars.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11324961

• Antibiotic-sparing strategies for bacterial infections

  A multi-project program aims to find smarter ways to treat infections caused by resistant bacteria while using antibiotics more sparingly.

  NIH research Washington University · Saint Louis, United States · NIH-11308781

• How OAS immune proteins help protect against bacteria that live inside cells

  This project looks at whether OAS immune proteins help the body's cells fight bacterial infections that live inside human cells.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11249644

• Understanding how certain proteins help the immune system fight bacterial infections

  This study is looking at how certain proteins in our immune system, called OAS proteins, can help our body fight off bacterial infections, which could lead to new ways to boost our immune response against these illnesses.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11245950

• Targeted antibacterial peptides to fight drug-resistant infections

  Researchers are designing new antimicrobial peptides to treat people with antibiotic-resistant bacterial infections.

  NIH research Purdue University · West Lafayette, United States · NIH-11172549

• New Antibiotics for Drug-Resistant Bacterial Infections

  This project is creating new antibiotics called biamyxins to fight serious infections caused by drug-resistant bacteria.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11129737

• A new peptide treatment for drug-resistant Gram-negative infections

  A lab-developed peptide called MTD12813 is being advanced as a potential treatment for people with dangerous multidrug-resistant Gram-negative bacterial infections like carbapenem-resistant Enterobacteriaceae.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11124824

• Investigating why treatment decisions vary for febrile infants at risk for serious infections

  This study is looking at how doctors make different choices when treating babies with fevers who might have serious infections, so we can find ways to improve their care and make sure all infants get the right treatment without unnecessary tests or treatments.

  NIH research University of Rochester · Rochester, United States · NIH-11109456

• Understanding Gut Infections Using Lab-Grown Intestinal Models

  This project uses tiny lab-grown models of human intestines to learn more about bacterial infections that cause diarrhea, especially in children.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11099870

• Understanding the Body's Defense Against Bacterial Infections

  This research explores how our immune system's internal alarm bells, called inflammasomes, detect and fight off bacterial invaders.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11099763

• Comparing the safety of antibiotics for common infections during pregnancy

  This study is looking at how safe different antibiotics are for pregnant women who need treatment for common infections, like urinary tract or respiratory infections, to help doctors choose the best options for their patients.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11093362

• Developing antibodies to combat antibiotic-resistant bacterial infections

  This study is working on new ways to help your immune system recognize and fight off tough bacteria by using special structures on their surface, which could lead to better vaccines and treatments for infections that don't respond to regular antibiotics.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11082422

• Understanding and predicting bacterial infections in hospitals during COVID-19.

  This study is looking at how to predict and manage infections that are resistant to antibiotics in hospitals, especially during the COVID-19 pandemic, so that doctors can better protect patients like you from these infections.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11031920

• Designing new antimicrobial peptides to fight bacterial infections

  This study is working on creating new types of treatments called antimicrobial peptides to help fight infections caused by bacteria that don't respond to regular antibiotics, using smart technology to find the best options while keeping them safe for patients.

  NIH research Purdue University · West Lafayette, United States · NIH-10915026

• How influenza virus causes bacterial infections in the lungs

  This study is looking at how the flu virus can make it easier for bacteria to cause infections in the lungs, especially by affecting the cells that help protect our airways, and it's for anyone interested in understanding how to better prevent these infections after getting the flu.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10901165

• New treatment for drug-resistant bacterial infections

  This study is testing a new treatment called Orynotide™ MTD12813 to help people with tough bacterial infections that don't respond to regular antibiotics, especially those caused by certain resistant germs.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10892236

• Using antibiotics to improve imaging of bacterial infections related to implants

  This study is testing a new way to spot tough infections caused by certain bacteria on medical devices like catheters and joint replacements, using a special tool that combines an antibiotic with a tracking agent, which could help doctors diagnose these infections more quickly and accurately.

  NIH research Washington University · Saint Louis, United States · NIH-10889540

• New antibiotics targeting drug-resistant Gram-negative bacterial infections

  This study is working on a new type of antibiotic called biamyxins to help fight tough infections caused by bacteria that don't respond to regular treatments, especially for patients dealing with serious healthcare-related infections.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-10859228

• Reducing serious infections and overdoses in people who inject drugs

  This study is looking for better ways to help people who inject drugs by finding out how to reduce the chances of serious infections and overdoses, so we can improve their health and safety in the long run.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10846815

• Investigating a bacterial mechanism to combat infections

  This study is looking at how certain bacteria, like those that cause urinary infections, grab important metal nutrients using tiny helpers called siderophores, and the researchers hope to find new ways to block this process to help create better treatments for infections.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10791920

• Developing a new method to treat bacterial infections without antibiotics

  This study is exploring a new way to fight bacterial infections by using specially designed bacteria that can share harmful genes with the bad bacteria, which could help create faster and cheaper treatments than traditional antibiotics.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10663838

• Detecting bacterial infections using advanced imaging techniques

  This study is testing a new imaging tool that helps doctors spot infections related to medical devices like joint implants earlier and more accurately, so patients can get better treatment sooner.

  NIH research Microbial Imaging, LLC · Lithia Springs, United States · NIH-10611527

Related topics

Quick answers

How many Bacterial Infections clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (3 trials), China (3 trials), Japan (3 trials), France (2 trials), Bosnia and Herzegovina (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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