Improving understanding and outcomes in Tuberculous meningitis
Translational approaches to improve understanding and outcome in Tuberculous meningitis
This study is looking at why some people with tuberculous meningitis, especially those with HIV, have a harder time recovering, and it aims to find better ways to treat this serious condition by exploring how the immune system works and how well medications reach the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-10808957 on NIH RePORTER |
What this research studies
This research focuses on Tuberculous meningitis (TBM), a severe form of tuberculosis that can lead to high mortality and long-term disabilities, particularly in vulnerable populations like those with HIV. The project aims to understand why some patients experience poor outcomes by investigating the immune responses and drug penetration into the brain. Researchers will develop tools and biomarkers to predict disease progression and treatment responses, utilizing clinical samples and a rabbit model for testing new therapies. By combining various scientific approaches, the study seeks to enhance treatment strategies for TBM.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with Tuberculous meningitis, especially those with compromised immune systems such as HIV patients.
Not a fit: Patients with Tuberculous meningitis who are not adults or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols and better outcomes for patients suffering from Tuberculous meningitis.
How similar studies have performed: Previous research has shown promise in understanding and treating Tuberculous meningitis, but this specific approach is innovative and aims to address gaps in current treatment strategies.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Gengenbacher, Martin Alfons — Hackensack University Medical Center
- Study coordinator: Gengenbacher, Martin Alfons
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.