How bacterial meningitis affects blood vessels in the brain
Impairment of the cerebral vasculature during bacterial meningitis
['FUNDING_R15'] · UNIVERSITY OF ALABAMA IN TUSCALOOSA · NIH-10795568
This study is looking at how bacterial meningitis affects the protective barrier around the brain, using special human cell models to see how bacteria can break through and cause problems, with the hope of finding new ways to help people who are dealing with this serious illness.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA IN TUSCALOOSA (nih funded) |
| Locations | 1 site (TUSCALOOSA, UNITED STATES) |
| Trial ID | NIH-10795568 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of bacterial meningitis on the blood-brain barrier, which protects the brain from harmful substances. By using advanced human stem-cell models, the study aims to understand how bacteria like Group B Streptococcus invade brain endothelial cells and disrupt their protective functions. The researchers will explore specific cellular processes that are altered during infection, which may lead to complications such as stroke. This work could provide insights into potential therapeutic targets to improve outcomes for patients affected by this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with bacterial meningitis, particularly those experiencing complications.
Not a fit: Patients with viral meningitis or other non-bacterial central nervous system infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent neurological damage in survivors of bacterial meningitis.
How similar studies have performed: Previous research has shown promising results in understanding the blood-brain barrier's role in CNS infections, but this specific approach using human stem-cell models is relatively novel.
Where this research is happening
TUSCALOOSA, UNITED STATES
- UNIVERSITY OF ALABAMA IN TUSCALOOSA — TUSCALOOSA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORRELL, ROBERT NATHAN — UNIVERSITY OF ALABAMA IN TUSCALOOSA
- Study coordinator: CORRELL, ROBERT NATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.