Condition

Lung Diseases clinical trials and research

• 31Clinical trials
• 31NIH research projects
• 34Countries

Newest Lung Diseases clinical trials

All recruiting trials (31)

• Electrical Impedance Tomography for Monitoring Lung Disease

  This test tries to see if a painless, noninvasive imaging method called electrical impedance tomography (EIT) can track how air is distributed in the lungs of adults with lung diseases and healthy volunteers and how those results match standard spirometry.

  Recruiting University Hospital Olomouc · Olomouc · NCT07356076

• Mosliciguat added to inhaled treprostinil for pulmonary hypertension from ILD

  This trial tests whether adding inhaled mosliciguat to your inhaled treprostinil is safe and tolerable for people with pulmonary hypertension caused by interstitial lung disease.

  Recruiting at 13 sites Phase 2 Pulmovant, Inc. · Santa Barbara, California and 12 other locations · NCT07333183

• Collecting lung sound recordings using Eko digital stethoscopes in clinic

  This project will try to teach computer programs to recognize wheeze, crackles, rhonchi, stridor, rales, and cough from stethoscope recordings in adults with suspected or diagnosed lung conditions and in people with normal lungs.

  Recruiting Eko Devices, Inc. · Mumbai, Maharashtra · NCT07270744

• Multi-omics prediction of graft problems after lung transplant

  We will test whether repeated blood and lung-fluid multi-omics tests can spot early graft dysfunction in adults after lung transplantation.

  Recruiting Shanghai Pulmonary Hospital, Shanghai, China · Shanghai · NCT07243964

• Recording lung sounds with Eko digital stethoscopes in clinic

  This project will test an AI that listens to lung sounds recorded with Eko digital stethoscopes to find abnormal sounds in people with or without lung disease.

  Recruiting at 2 sites Eko Devices, Inc. · Jacksonville, Florida and 1 other locations · NCT07227376

• Trop2- and EpCAM-targeted PET/CT to help distinguish non-small cell lung cancer

  This project will test whether PET/CT scans that target Trop2 and EpCAM can show protein expression in tumors of people with suspected non-small cell lung cancer.

  Recruiting RenJi Hospital · Shanghai · NCT07026110

• Early intervention strategies for lung cancer detection

  This study is testing if using low-dose CT scans in community health centers can help find lung cancer earlier in people aged 40-75 who don't have a history of the disease.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06988943

• Comparing PET/CT guided biopsy and CT guided biopsy for lung lesions

  This study is testing whether a PET/CT guided biopsy can provide better results than a traditional CT guided biopsy for people with suspected lung tumors.

  Recruiting All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT06923098

• Cemiplimab guided by ctDNA levels (PALACE)

  This study will see if starting adults with advanced (stage IIIB/C or IV) non-small cell lung cancer and PD-L1 ≥50% on cemiplimab, then using ctDNA and early scans to decide whether to add chemotherapy, can improve overall survival.

  Recruiting at 19 sites Phase 2 Fundación GECP · Alicante, Alicante and 19 other locations · NCT06917573

• Teniposide after prior therapy for c-Myc–driven extensive-stage small cell lung cancer

  This will try teniposide in people with extensive-stage small cell lung cancer driven by high c-Myc who have progressed after standard treatment.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT06758700

• Re-examination of participants from the Swedish CArdioPulmonary bioImage Study

  This study is looking at around 15,000 people from a previous heart and lung health study to see how their conditions have changed over the years and to improve ways to predict and prevent heart and lung diseases.

  Recruiting at 6 sites Karolinska Institutet · Gothenburg and 5 other locations · NCT06679777

• Inhaled liposomal amikacin (Arikayce) for Mycobacterium xenopi lung infection

  This trial will test inhaled liposomal amikacin (Arikayce) alongside standard antibiotics to see if it helps adults with Mycobacterium xenopi lung disease.

  Recruiting Phase 2 Centre Hospitalier Universitaire, Amiens · Amiens · NCT06585020

• Preventing Cytomegalovirus Disease in Lung Transplant Recipients

  This study looks at how lung transplant patients' immune systems respond to Cytomegalovirus to see if it can help prevent disease after their transplant.

  Recruiting University of Miami · Miami, Florida · NCT06494033

• Treatment for lung cancer patients who had surgery but are not disease-free

  This study is testing two new immunotherapy treatments for lung cancer patients who have had surgery but still have some disease to see if they can help them stay cancer-free longer.

  Recruiting at 31 sites Phase 3 Fundación GECP · Alicante, Alicante and 31 other locations · NCT06431633

• Understanding lung health in young adults

  This study is trying to learn more about lung health in healthy young adults aged 25 to 35 by testing how well their lungs work and what might affect their risk of lung disease.

  Recruiting at 12 sites Johns Hopkins University · Birmingham, Alabama and 11 other locations · NCT06177717

• Evaluating hemodiafiltration for improving marginal donor lungs during ex vivo lung perfusion

  This study is testing if a new method called hemodiafiltration can help improve the condition of certain donor lungs during a special treatment process to make them better for transplantation.

  Recruiting Medical University of Vienna · Vienna · NCT06082401

• Using cryogenic catheters for lung biopsy and treatment

  This study is testing a new way to take lung biopsies and treat lung lesions using cold technology to see if it can be safer and more effective than traditional methods.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT05948904

• Using belumosudil to prevent or treat bronchiolitis obliterans in stem cell transplant patients

  This study is testing if a new medication called belumosudil can help prevent or treat bronchiolitis obliterans in patients who have recently had a stem cell transplant.

  Recruiting at 4 sites Phase 2 Dana-Farber Cancer Institute · Stanford, California and 5 other locations · NCT05922761

• Using cough samples to analyze lung health

  This study is testing whether cough samples can help us find signs of lung diseases by comparing them to samples taken from healthy people and smokers.

  Recruiting Albert Einstein College of Medicine · The Bronx, New York · NCT05854563

• Comparing two methods of lung ventilation during lung cancer surgery

  This study is testing two different ways of helping patients breathe during lung cancer surgery to see which method works better for keeping their lungs safe and improving recovery.

  Recruiting University Hospital, Montpellier · Montpellier · NCT05525312

• Assessing heart function in swimmers with pulmonary edema

  This study looks at how swimming-induced pulmonary edema affects heart function in swimmers during a big open water event in Sweden to see how it differs between those with symptoms and those without.

  Recruiting Dalarna County Council, Sweden · Falun · NCT05391737

• Effects of Trikafta on exercise and breathing in cystic fibrosis patients

  This study tests how the drug Trikafta affects breathing and exercise ability in people with cystic fibrosis.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05279040

• Comparing robotic and video-assisted lung surgery techniques

  This study is testing whether robotic lung surgery works better and is safer than video-assisted lung surgery for patients needing lung removal.

  Recruiting The Second Hospital of Shandong University · Jinan, Shandong · NCT05270616

• Using a PEP-device to treat swimming-induced pulmonary edema

  This study is testing if using a special breathing device for 20 minutes can help swimmers recover faster from swimming-induced pulmonary edema compared to not using the device.

  Recruiting Dalarna County Council, Sweden · Falun · NCT05227222

• Assessing respiratory muscle function in children

  This study tests how strong the breathing muscles are in children with breathing problems to see if better treatments can help them breathe easier.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05051254

• Longitudinal study on lung health in young adults

  This study is looking at how things like the environment, exercise, and health markers affect lung health in young adults aged 25-35 over the next few years.

  Recruiting at 27 sites Johns Hopkins University · Birmingham, Alabama and 36 other locations · NCT04543461

• Monitoring long-term effects of SARS-CoV-2 infections

  This study follows patients who were hospitalized with COVID-19 to see how the virus has affected their lungs and heart over the long term.

  Recruiting University of Giessen · Giessen · NCT04442789

• Comparing oxygen and CPAP for treating swimming induced pulmonary edema

  This study tests whether using CPAP along with oxygen helps swimmers with swimming induced pulmonary edema feel better than just using oxygen alone.

  Recruiting Dalarna County Council, Sweden · Falun · NCT04307615

• Comparing clinical surveillance to anticoagulation for low-risk patients with isolated pulmonary embolism

  This study is testing whether low-risk patients with isolated pulmonary embolism can safely be monitored without blood thinners instead of taking them.

  Recruiting at 29 sites Phase 4 Insel Gruppe AG, University Hospital Bern · Woluwe-Saint-Lambert, Brussels Capital and 39 other locations · NCT04263038

• Comparing home-based and hospital-based pulmonary rehabilitation for bronchiectasis

  This study is testing whether doing pulmonary rehabilitation at home or in the hospital is better for people with bronchiectasis to see which helps them breathe easier and feel better.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Zeytinburnu · NCT03561818

• Examining health determinants and their impact on chronic diseases

  This study looks at how personal choices and community factors affect heart health and other long-term illnesses to see what really impacts people's health.

  Recruiting at 34 sites Population Health Research Institute · Rosario, Santa Fe Province and 33 other locations · NCT03225586

NIH-funded research (31)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Clinical readiness for rare lung diseases (RLDC)

  A group at the University of Cincinnati is building a program to speed up care for people with rare lung diseases by tracking patients over time, improving tests and treatments, and sharing information with patients and clinicians.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11453391

• Epithelial cells trigger fibroblast activation in lung fibrosis through CTHRC1-TGFb signaling

  A clinician-scientist at Duke is studying how lung lining cells may turn normal fibroblasts into fibrosis-causing cells, aiming to uncover new targets for treatment of diseases like BO and IPF.

  NIH research Duke University · Durham, United States · NIH-11415775

• Molecular origins of chronic lung diseases in the human lung

  Researchers are mapping the tiny cell neighborhoods in diseased lungs to find early clues that could protect or restore normal lung function.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11415568

• How lung cells and their surroundings drive fibrosis in interstitial lung diseases

  A study to understand how airway cells, surrounding tissue, and their environment contribute to progressive scarring in interstitial lung diseases.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11412613

• Loss of Cilia Maintenance in Acquired and Genetic Lung Diseases

  Researchers are studying why tiny hair-like structures in the lungs lose their maintenance and how this affects people with asthma, COPD, and related airway diseases.

  NIH research Washington University · Saint Louis, United States · NIH-11400358

• CMKLR1-targeted imaging to map lung inflammation in ALI and fibrotic lung diseases

  A study to test a new PET imaging tool that targets CMKLR1 to visualize lung inflammation and help predict and monitor disease progression in patients with acute lung injury and fibrotic lung diseases.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11399810

• Quantitative Ultrasound for Lung Diseases in People

  A new ultrasound approach to measure how bad heart- or fibrosis-related lung problems are, using real-time, noninvasive imaging in people.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11367435

• Bispecific immunotherapy delivery system for lung diseases

  A new dual-precision delivery method is being developed to get immune therapies directly into the lungs to treat ARDS and related conditions.

  NIH research Proteogenomics Research Instit/sys/ Med · La Jolla, United States · NIH-11359649

• Maternal viral infections and child lung health: how prenatal exposure can shape future breathing problems

  A mother’s viral infection during pregnancy may influence her baby’s lungs after birth, potentially increasing the risk of inflammatory lung conditions like asthma.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11343972

• Better Lung Imaging for Conditions like Pulmonary Fibrosis

  This work explores a new ultrasound method to better track lung conditions like heart failure-related fluid buildup and idiopathic pulmonary fibrosis in people.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11193973

• Ready-to-use quality improvement tools for lung conditions

  This project builds ready-made software templates hospitals can plug into their systems to help improve care for people with asthma, COPD, and other lung problems.

  NIH research Phrase Health, INC. · Philadelphia, United States · NIH-11193804

• PET imaging to find and track harmful lung inflammation via CMKLR1

  A new PET scan tracer that targets CMKLR1 is being developed to find and track harmful lung inflammation in people with acute lung injury, ARDS, and fibrotic lung diseases.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11181300

• Understanding the molecular roots of long-term lung scarring

  This project maps cells and signals in damaged adult lungs to find early molecular targets that might stop or reverse scarring in chronic lung disease.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11178774

• How lung cell and tissue interactions cause scarring in interstitial lung disease

  This project looks at how injured lung lining cells talk with nearby cells and the surrounding tissue to cause scarring in people with interstitial lung disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11178483

• Using targeted nanomedicine to treat lung diseases caused by viruses

  This study is exploring new ways to deliver treatments directly to the lungs using tiny particles, aiming to help people with serious lung diseases like COVID-19 and other viral infections, so they can get better care and feel healthier.

  NIH research University of Chicago · Chicago, United States · NIH-11111257

• New drug delivery system for treating lung diseases

  This study is testing a new way to deliver medicine directly to the lungs to help people with lung diseases like Acute Respiratory Distress Syndrome (ARDS), aiming to make treatments work better while causing fewer side effects.

  NIH research Proteogenomics Research Instit/sys/ Med · La Jolla, United States · NIH-11103179

• Investigating genetic mutations in lung diseases using advanced editing techniques

  This study is looking at how changes in a specific gene can affect lung diseases like cystic fibrosis and asthma, and it aims to fix these changes in lung cells to help improve treatments for people living with these conditions.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11092296

• Investigating personalized treatment options for Idiopathic Pulmonary Fibrosis using genetic information.

  This study is looking to help people with Idiopathic Pulmonary Fibrosis (IPF) by using their genetic information to find the best treatments for them, so they can get care that’s more personalized and effective.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11075126

• Investigating personalized treatment options for Idiopathic Pulmonary Fibrosis using genetic information

  This study is looking to make treatments for Idiopathic Pulmonary Fibrosis (IPF) better by using genetic information to find out how different people respond to medications like N-Acetylcysteine, so that doctors can provide more personalized care for patients with lung diseases.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11071971

• Identifying immune cell changes in chronic lung diseases using advanced sequencing techniques.

  This study is looking at how immune cells change in people with chronic lung diseases to find new ways to diagnose and treat conditions like idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis, using a simple blood test.

  NIH research Yale University · New Haven, United States · NIH-11017010

• Investigating the role of the complement pathway in lung diseases

  This study is looking at how certain proteins in your body might help us understand the progression of idiopathic pulmonary fibrosis and similar lung diseases, so we can find better treatments tailored just for you.

  NIH research Duke University · Durham, United States · NIH-11011341

• Investigating lung diseases caused by mycobacteria in Virginia

  This study is looking at lung infections caused by certain bacteria that are getting more common and harder to treat, and it's for people who have these infections; researchers want to learn more about how these infections come back or happen again, and how different treatments work for patients.

  NIH research University of Virginia · Charlottesville, United States · NIH-11003313

• Understanding how cell interactions contribute to lung disease fibrosis

  This study is looking at how different cells in the lungs work together to cause scarring in interstitial lung diseases, especially in the early stages, to help find new ways to treat the condition.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10975694

• Understanding the cellular causes of chronic lung diseases

  This study is looking at how the cells in your lungs work together and change when you have chronic lung diseases like pulmonary fibrosis and bronchopulmonary dysplasia, with the goal of finding new ways to help improve lung health.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10975485

• Using ultrasound to assess lung diseases like pulmonary edema and fibrosis

  This study is looking at how low-quality ultrasound can help check the severity of lung problems like fluid buildup from heart failure and lung scarring, aiming to offer a safer and cheaper way to monitor these conditions without the radiation from X-rays or CT scans.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-10945844

• A new inhalation treatment for lung diseases caused by mucus buildup

  This study is testing a new inhaler solution that combines two ingredients to help people with lung diseases like COPD, asthma, and cystic fibrosis breathe better by clearing out mucus that blocks their airways.

  NIH research Parion Sciences, INC. · Durham, United States · NIH-10918480

• Creating new cell therapies for lung diseases using AI technology

  This study is exploring a new way to help people with idiopathic pulmonary fibrosis (IPF) by using artificial intelligence to turn skin cells into lung cells, which could lead to better treatments for this serious lung disease.

  NIH research Cellforma, INC · Boston, United States · NIH-10913890

• Using a targeted imaging technique to assess lung inflammation in acute lung injury and fibrotic lung diseases

  This study is testing a new type of PET scan that can help see and measure inflammation in the lungs, which could be really helpful for people with lung injuries or diseases like fibrosis, including those affected by COVID-19, to better understand their condition and tailor their treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10912806

• Training program for improving children's lung health

  This program at the Children's Hospital of Philadelphia is all about helping new researchers learn how to study and improve treatments for kids with lung problems like cystic fibrosis and asthma, so they can make a real difference in children's health.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10884155

• Creating a library of quality improvement tools for lung diseases

  This study is creating easy-to-use tools for doctors and healthcare workers to help them make better decisions when treating patients with lung diseases, so they can provide even better care.

  NIH research Phrase Health, INC. · Philadelphia, United States · NIH-10820664

• Improving health interventions for heart and lung diseases through implementation science.

  This study is all about helping doctors and health workers use the best treatments for heart and lung diseases in everyday settings, especially for people who might not get the care they need, so that everyone can benefit from effective healthcare.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10809592

Related topics

Quick answers

How many Lung Diseases clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 34 countries. The most sites are in United States (7 trials), China (6 trials), Sweden (5 trials), France (4 trials), Canada (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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