Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using cryogenic catheters for lung biopsy and treatment

Official title: Defining a Technique for the Use of Cryogenic Catheters for Biopsy and Ablation for the Diagnostic and Treatment of Pulmonary Lesions: An Ex-Vivo Human Lung Model Study.

Run by Centre hospitalier de l'Université de Montréal (CHUM) · NCT05948904 · Data updated 2026-11-12

This study is testing a new way to take lung biopsies and treat lung lesions using cold technology to see if it can be safer and more effective than traditional methods.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorCentre hospitalier de l'Université de Montréal (CHUM)
Academic / other
Locations1 site (Montreal, Quebec)
StatusRecruiting
StartedNovember 3, 2023
Main results expectedApril 1, 2027
Study endsApril 1, 2027
Registry record updatedMarch 18, 2026
Trial IDNCT05948904 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients undergoing lung transplant surgery.

Probably not a fit

Patients who are organ donors ineligible to donate lungs or healthy individuals may not receive any benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a standardized technique for using cryogenic catheters in transbronchial cryobiopsy and cryoablation of pulmonary lesions. By utilizing an ex-vivo human lung model, the researchers will explore the effectiveness of cryotechnology as a minimally invasive alternative to traditional surgical lung biopsy and resection. The goal is to improve the quality of tissue samples and reduce complications associated with current methods. This approach could enhance patient safety and outcomes in lung disease management.

Why it matters

Potential benefit: If successful, this technique could provide a safer and more effective method for diagnosing and treating lung lesions.

How similar studies have gone: While promising results have been achieved using cryotechnology, this specific approach to transbronchial interventions is novel and has not been extensively tested in humans.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients undergoing lung transplant surgery

Exclusion Criteria:

* Organ donor ineligible to donate lungs
* Healthy individuals

Where it's running

  • Chum
    Montreal, Quebec, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.