Assessing respiratory muscle function in children
Respiratory Muscles and Work of Breathing in Children
NA · Assistance Publique - Hôpitaux de Paris · NCT05051254
This study tests how strong the breathing muscles are in children with breathing problems to see if better treatments can help them breathe easier.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 550 (estimated) |
| Ages | 0 Years to 17 Years |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Paris) |
| Trial ID | NCT05051254 on ClinicalTrials.gov |
What this trial studies
This study evaluates respiratory muscle strength in children with respiratory impairments using esogastric pressure measurements. It aims to understand the pathophysiology of respiratory issues and guide therapeutic management by detecting muscle dysfunction or paralysis. The study includes children under 18 years old who are either breathing spontaneously or on mechanical ventilation. By comparing muscle strength before and after treatment, the study seeks to optimize respiratory management and potentially improve patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are children under 18 years old with primary or secondary respiratory muscle impairment.
Not a fit: Patients with significant psychomotor retardation or those unable to cooperate may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management of respiratory conditions in children, improving their quality of life.
How similar studies have performed: Other studies using similar respiratory muscle testing approaches have shown promise, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged less than 18 years old with primary or secondary impairment of respiratory muscles and followed at Necker Hospital * Patients under spontaneous breathing or noninvasive or invasive mechanical ventilation * Written informed consent Exclusion Criteria: * No social insurance * Significant psychomotor retardation * Absence of cooperation * Significant agitation * Hemodynamic instability * Acute condition or temporary drug treatments that may interfere with the results of the respiratory muscle explorations
Where this trial is running
Paris
- Hôpital Necker-Enfants Malades — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Brigitte FAUROUX, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Brigitte FAUROUX, MD, PhD
- Email: brigitte.fauroux@aphp.fr
- Phone: 1 71 19 60 92
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neuromuscular Diseases, Congenital Diaphragmatic Hernia, Lung Diseases, Cardiac Diseases, Scoliosis, Diaphragmatic Impairment, Respiratory Muscle Impairment, Respiratory muscle testing