Comparing two methods of lung ventilation during lung cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates two different strategies for one-lung ventilation (OLV) during lung resection surgery for cancer patients. The study aims to determine the effectiveness of an 'open-lung' protective ventilation strategy, which adjusts positive end-expiratory pressure (PEEP) based on individual patient characteristics, compared to a standard PEEP approach. By measuring transpulmonary pressure using an esophageal catheter, the trial seeks to improve oxygenation and reduce respiratory complications associated with OLV. The findings could provide insights into optimizing ventilation strategies for better surgical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* To be over 18 years old,
* To be able to attend all scheduled visits and to comply with all trial procedures,
* To be scheduled for a lung cancer resection surgery (performed by either video-assisted thoracoscopy or thoracotomy).

Exclusion Criteria:

* Non-carcinologic indication of lung resection (e.g. Lung volume reduction for bullous emphysema reduction, lung abscess),
* Bilateral pulmonary resection surgery or history of lung resection surgery,
* Lung resection under sternotomy
* Non intubated video-assisted thoracoscopy
* Robotic thoracic surgery
* Contraindication to esophageal catheter (history of esophageal varices, hepatic cirrhosis child ≥ b, esophageal or gastric surgery, thoracic radiotherapy, latex allergy),
* ASA (American Society of Anesthesiologists) score ≥ 4,
* Chronic obstructive pulmonary disease GOLD III or IV (Forced Expiratory Volume, FEV\<50%),
* Uncontrolled asthma (FEV \<50%),
* Intracardiac shunt,
* Hemoglobinopathy making the SpO2 values invalid,
* Heart failure NYHA III or IV,
* Documented pulmonary hypertension (Mean Pulmonary Arterial Pressure at rest, mPAP\>20 mmHg),
* To be under legal protection,
* Unable to read or write,
* Lack of informed consent, or unable to give consent,
* Refusal to participate in the study,
* Pregnancy in progress or planned during the study period, pregnant or nursing women,
* Not being affiliated to a French social security system or being a beneficiary of such a system.

Where it's running

• Département d'Anesthésie et Réanimation Cardiothoracique - CHU Arnaud de Villeneuve
  Montpellier, France Recruiting

Study contacts

• Study coordinator: Hélène Dr DAVID
• Email: h-david@chu-montpellier.fr
• Phone: 06.65.84.95.24

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.