Understanding lung health in young adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate lung structure and function in a cohort of 1000 healthy individuals aged 25 to 35. Participants will undergo four different lung function tests to assess various aspects of lung health, including air movement, lung size, and gas exchange capabilities. The study leverages the infrastructure of the American Lung Association's Airways Clinical Research Centers to form a national cohort focused on respiratory health, examining factors that may influence lung disease susceptibility. By analyzing these factors, the study seeks to establish a comprehensive understanding of lung health and identify early indicators of chronic lung disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 25-35 years at the time of the baseline examination
* Able to read and understand English or Spanish
* Has a social security number
* Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination.

Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation.

* Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant

Exclusion Criteria:

1. Severe asthma, which is defined as any of the following:

   * Current (i.e. at the time of the visit) Global Initiative for Asthma (GINA) Step 4 or higher therapy (medium dose inhaled corticosteroid/long-acting beta agonist (ICS/LABA) or high dose inhaled corticosteroid \[ICS\] or add-on long-acting muscarinic antagonist (LAMA); Medium dose = \>250 fluticasone, propionate =100 fluticasone furoate, \>200 beclomethasone, \>400 budesonide, \>220 mometasone). The investigators will accept low-dose ICS/LABA or medium dose ICS.

   OR
   * 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR
   * One asthma hospitalization in the past 12 months
2. History of any chronic lung disease other than asthma including but not limited to chronic obstructive pulmonary disease (COPD), cystic fibrosis, pulmonary fibrosis, pulmonary hypertension
3. Current pregnancy
4. History of cancer other than non-melanoma skin cancer
5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease)
6. Inability to comply with study procedures, including

   * Inability or unwillingness to provide informed consent
   * Inability to perform study measurements
   * Inability to be contacted by phone (via calls and/or text messaging) or email
7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit).
8. Institutionalization

Where it's running

• University of Alabama
  Birmingham, Alabama, United States Recruiting
• University of California, Los Angeles
  Los Angeles, California, United States Recruiting
• National Jewish Health
  Denver, Colorado, United States Recruiting
• Nemours Children's Jacksonville
  Jacksonville, Florida, United States Recruiting
• Northwestern University
  Chicago, Illinois, United States Recruiting
• University of Kansas
  Kansas City, Kansas, United States Recruiting

Study contacts

• Principal investigator: Meredith McCormack, MD — Johns Hopkins University
• Study coordinator: Meredith McCormack, MD
• Email: mmccor16@jhmi.edu
• Phone: 410-955-3467

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.