Clinical readiness for rare lung diseases (RLDC)
Official title: Clinical Trial Readiness for Rare Lung Diseases
Funded at University of Cincinnati · NIH-11453391 · Data updated 2026-11-12
A group at the University of Cincinnati is building a program to speed up care for people with rare lung diseases by tracking patients over time, improving tests and treatments, and sharing information with patients and clinicians.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 5, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,757,695 |
| NIH project number | 1U54HL188781-01 |
| Project ID | NIH-11453391 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with rare lung diseases such as Birt-Hogg-Dubé syndrome, LAM, pulmonary Langerhins cell histiocytosis, PAP, and familial interstitial pneumonias who are willing to participate in longitudinal follow-up.
✕Less likely to help
Patients not eligible may include those without a diagnosed rare lung disease or those unable to commit to long-term follow-up.
What this research studies
This program brings together clinicians and researchers to follow patients with diseases like Birt-Hogg-Dubé syndrome and other diffuse cystic lung diseases over time. They will collect natural history data, develop new diagnostic tools, and work on therapies while providing training for clinical research and creating educational materials for patients and doctors. The effort leverages remote and clinic-based monitoring to keep patients engaged and to advance translational work. It includes collaboration with patient advocacy groups and aims to streamline pathways from discovery to potential therapies.
Why it matters
Potential benefit: If successful, patients could see faster access to better diagnostics and treatments and improved information to guide care.
How similar studies have gone: This approach builds on prior NIH-funded, collaborative research showing that longitudinal monitoring can accelerate therapeutic development in rare lung diseases.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Mccormack, Francis Xavier — University of Cincinnati
- Study coordinator: Mccormack, Francis Xavier
Related research
Other NIH-funded projects on the same topics.
-
Epithelial cells trigger fibroblast activation in lung fibrosis through CTHRC1-TGFb signaling
A clinician-scientist at Duke is studying how lung lining cells may turn normal fibroblasts into fibrosis-causing cells, aiming to uncover new targets for treatment of diseases like BO and IPF.
-
Molecular origins of chronic lung diseases in the human lung
Researchers are mapping the tiny cell neighborhoods in diseased lungs to find early clues that could protect or restore normal lung function.
-
How lung cells and their surroundings drive fibrosis in interstitial lung diseases
A study to understand how airway cells, surrounding tissue, and their environment contribute to progressive scarring in interstitial lung diseases.
-
Loss of Cilia Maintenance in Acquired and Genetic Lung Diseases
Researchers are studying why tiny hair-like structures in the lungs lose their maintenance and how this affects people with asthma, COPD, and related airway diseases.
-
CMKLR1-targeted imaging to map lung inflammation in ALI and fibrotic lung diseases
A study to test a new PET imaging tool that targets CMKLR1 to visualize lung inflammation and help predict and monitor disease progression in patients with acute lung injury and fibrotic lung diseases.
-
Quantitative Ultrasound for Lung Diseases in People
A new ultrasound approach to measure how bad heart- or fibrosis-related lung problems are, using real-time, noninvasive imaging in people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.