Understanding the cellular causes of chronic lung diseases
Unraveling the molecular origins of chronic parenchymal lung diseases
This study is looking at how the cells in your lungs work together and change when you have chronic lung diseases like pulmonary fibrosis and bronchopulmonary dysplasia, with the goal of finding new ways to help improve lung health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10975485 on NIH RePORTER |
What this research studies
This research investigates the cellular organization and changes in the human lung that contribute to chronic lung diseases like pulmonary fibrosis and bronchopulmonary dysplasia. By using advanced single-cell genomic techniques, the study aims to create a detailed molecular atlas that maps the cellular interactions and signaling pathways involved in these diseases. The researchers will focus on how disruptions in cell communication within the lung's specialized environments lead to disease progression. This approach seeks to identify early molecular targets that could be stabilized or reversed to improve lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chronic lung diseases such as pulmonary fibrosis or bronchopulmonary dysplasia.
Not a fit: Patients with acute lung conditions or those without chronic lung diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that stabilize or reverse chronic lung diseases, improving patient outcomes.
How similar studies have performed: Previous research using single-cell genomic studies has shown promise in understanding lung diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Kropski, Jonathan Andrew — Vanderbilt University Medical Center
- Study coordinator: Kropski, Jonathan Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.