Investigating lung diseases caused by mycobacteria in Virginia
Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
This study is looking at lung infections caused by certain bacteria that are getting more common and harder to treat, and it's for people who have these infections; researchers want to learn more about how these infections come back or happen again, and how different treatments work for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11003313 on NIH RePORTER |
What this research studies
This research focuses on nontuberculous mycobacterial lung diseases, particularly those caused by the M. avium complex, which are becoming increasingly common and challenging to treat. The project involves whole genome sequencing of mycobacterial isolates from patients to understand the differences between relapse and reinfection, as well as identifying environmental sources of these infections. Additionally, it will analyze a cohort of new patients to correlate clinical outcomes with various factors, including drug susceptibility and serum drug levels. This comprehensive approach aims to improve understanding and treatment of these complex lung diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with nontuberculous mycobacterial lung diseases, particularly those caused by the M. avium complex.
Not a fit: Patients with other types of lung diseases not related to mycobacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies and improved outcomes for patients suffering from mycobacterial lung diseases.
How similar studies have performed: Previous research has shown promise in using genomic sequencing and epidemiological approaches to understand and treat infectious diseases, indicating that this approach could be effective.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Houpt, Eric R — University of Virginia
- Study coordinator: Houpt, Eric R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.