Investigating lung diseases caused by mycobacteria in Virginia
Official title: Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
Funded at University of Virginia · NIH-11003313 · Data updated 2026-11-12
This study is looking at lung infections caused by certain bacteria that are getting more common and harder to treat, and it's for people who have these infections; researchers want to learn more about how these infections come back or happen again, and how different treatments work for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $530,209 |
| NIH project number | 5R01HL155547-05 |
| Project ID | NIH-11003313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with nontuberculous mycobacterial lung diseases, particularly those caused by the M. avium complex.
✕Less likely to help
Patients with other types of lung diseases not related to mycobacterial infections may not benefit from this research.
What this research studies
This research focuses on nontuberculous mycobacterial lung diseases, particularly those caused by the M. avium complex, which are becoming increasingly common and challenging to treat. The project involves whole genome sequencing of mycobacterial isolates from patients to understand the differences between relapse and reinfection, as well as identifying environmental sources of these infections. Additionally, it will analyze a cohort of new patients to correlate clinical outcomes with various factors, including drug susceptibility and serum drug levels. This comprehensive approach aims to improve understanding and treatment of these complex lung diseases.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies and improved outcomes for patients suffering from mycobacterial lung diseases.
How similar studies have gone: Previous research has shown promise in using genomic sequencing and epidemiological approaches to understand and treat infectious diseases, indicating that this approach could be effective.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Houpt, Eric R — University of Virginia
- Study coordinator: Houpt, Eric R
Related research
Other NIH-funded projects on the same topics.
-
Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
-
Learning from remission and relapse in lupus (SLE)
Researchers are studying people with systemic lupus erythematosus who are in long-term remission without steroids or immunosuppressants to understand their immune cells, brain function, and what might predict relapse.
-
Learning from Remission and Relapse in SLE
A program to study people with systemic lupus erythematosus who are in long-term remission to understand immune and brain signals that might predict relapse.
-
Alternative NF-kB activation after chemotherapy in ovarian cancer
This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.
-
Predictors of autoimmunity onset and relapse in skin
A study to understand what biological signals in skin predict when autoimmune diseases start, flare, or worsen in people at risk.
-
Clinical readiness for rare lung diseases (RLDC)
A group at the University of Cincinnati is building a program to speed up care for people with rare lung diseases by tracking patients over time, improving tests and treatments, and sharing information with patients and clinicians.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.