Quantitative Ultrasound for Lung Diseases in People
Official title: Quantitative Ultrasound for Interstitial Lung Diseases
Funded at North Carolina State University Raleigh · NIH-11367435 · Data updated 2026-11-12
A new ultrasound approach to measure how bad heart- or fibrosis-related lung problems are, using real-time, noninvasive imaging in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $655,005 |
| NIH project number | 5R01HL175513-03 |
| Project ID | NIH-11367435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with pulmonary edema from heart failure or idiopathic pulmonary fibrosis who require monitoring.
✕Less likely to help
Patients without lung edema or fibrosis or those not needing frequent imaging may not benefit.
What this research studies
This project tests a noninvasive ultrasound technique to quantify lung changes caused by heart failure–related edema and idiopathic pulmonary fibrosis. It aims to provide real-time measurements that could replace or reduce CT scans and chest X-rays, which expose patients to radiation or are costly. The study focuses on making ultrasound a reliable, point‑of‑care tool to monitor disease progression in patients with lung conditions.
Why it matters
Potential benefit: If successful, patients could be monitored more often with a quick, noninvasive test that avoids radiation and reduces the need for costly imaging.
How similar studies have gone: Previous ultrasound approaches have shown promise but are limited by qualitative measures; this work seeks quantitative biomarkers for better accuracy.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Muller, Marie — North Carolina State University Raleigh
- Study coordinator: Muller, Marie
Related research
Other NIH-funded projects on the same topics.
-
Better Lung Imaging for Conditions like Pulmonary Fibrosis
This work explores a new ultrasound method to better track lung conditions like heart failure-related fluid buildup and idiopathic pulmonary fibrosis in people.
-
Using ultrasound to assess lung diseases like pulmonary edema and fibrosis
This study is looking at how low-quality ultrasound can help check the severity of lung problems like fluid buildup from heart failure and lung scarring, aiming to offer a safer and cheaper way to monitor these conditions without the radiation from X-rays or CT scans.
-
How lung cells and their surroundings drive fibrosis in interstitial lung diseases
A study to understand how airway cells, surrounding tissue, and their environment contribute to progressive scarring in interstitial lung diseases.
-
How lung cell and tissue interactions cause scarring in interstitial lung disease
This project looks at how injured lung lining cells talk with nearby cells and the surrounding tissue to cause scarring in people with interstitial lung disease.
-
Investigating personalized treatment options for Idiopathic Pulmonary Fibrosis using genetic information.
This study is looking to help people with Idiopathic Pulmonary Fibrosis (IPF) by using their genetic information to find the best treatments for them, so they can get care that’s more personalized and effective.
-
Investigating personalized treatment options for Idiopathic Pulmonary Fibrosis using genetic information
This study is looking to make treatments for Idiopathic Pulmonary Fibrosis (IPF) better by using genetic information to find out how different people respond to medications like N-Acetylcysteine, so that doctors can provide more personalized care for patients with lung diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.