Preventing Cytomegalovirus Disease in Lung Transplant Recipients
Official title: Prophylaxis Guided by Cytomegalovirus-specific T Cell Immunity to Prevent Cytomegalovirus Disease in Lung Transplant Recipients: a Single Center Prospective Study
Run by University of Miami · NCT06494033 · Data updated 2026-11-12
This study looks at how lung transplant patients' immune systems respond to Cytomegalovirus to see if it can help prevent disease after their transplant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Miami Academic / other |
| Locations | 1 site (Miami, Florida) |
| Status | Recruiting |
| Started | July 3, 2024 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | March 23, 2026 |
| Trial ID | NCT06494033 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult lung transplant candidates over 18 years of age with a positive CMV IgG.
✕Probably not a fit
Patients who are HIV infected, pregnant or breastfeeding, or those with negative CMV IgG prior to transplant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the clinical outcomes related to Cytomegalovirus (CMV) in lung transplant recipients by monitoring their immunological responses to the virus. Participants will be followed to assess how their immune systems respond to CMV, particularly focusing on those with positive CMV IgG. The study will involve lung transplant candidates who are expected to undergo either single or double lung transplants.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of CMV disease in lung transplant recipients, improving their overall health outcomes.
How similar studies have gone: While this approach is focused on CMV-specific T cell immunity, similar studies have shown promise in managing viral infections in transplant populations, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adult patients over 18 years of age 2. Lung transplant candidates with positive CMV IgG 3. Anticipated to receive a lung transplant (both double lung and single lung) Exclusion Criteria: 1. Negative CMV IgG prior transplant 2. Pregnant or breastfeeding women 3. HIV infected patients 4. Combined organ (e.g., lung-heart, lung-kidney) transplant candidates
Where it's running
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University of Miami
Miami, Florida, United States Recruiting
Study contacts
- Principal investigator: Yoichiro Natori, MD — University of Miami
- Study coordinator: Yoichiro Natori, MD
- Email: yxn138@med.miami.edu
- Phone: 3053556323
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.