Electrical Impedance Tomography for Monitoring Lung Disease
The Use of Electrical Impedance Tomography (EIT) in Pulmonary Diseases
This test tries to see if a painless, noninvasive imaging method called electrical impedance tomography (EIT) can track how air is distributed in the lungs of adults with lung diseases and healthy volunteers and how those results match standard spirometry.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Olomouc Academic / other |
| Locations | 1 site (Olomouc) |
| Trial ID | NCT07356076 on ClinicalTrials.gov |
What this trial studies
This observational study will use Electrical Impedance Tomography (EIT) to record real-time, spatial patterns of lung ventilation in adults with a range of lung diseases and in healthy volunteers. Participants will undergo noninvasive EIT recordings alongside standard seated spirometry when possible, and a subgroup who cannot perform spirometry will be included to examine EIT utility without forced breathing. Investigators will compare EIT images with spirometry measures and normal reference data to identify ventilation patterns associated with different lung conditions. The work is conducted at the Department of Pulmonary Diseases and Tuberculosis, University Hospital Olomouc.
Who should consider this trial
Good fit: Adults aged 18 or older with COPD, asthma, pulmonary fibrosis, pneumonia, or residual post-COVID lung findings, as well as healthy volunteers (non-smokers or ex-smokers) who can attend testing, are the ideal candidates.
Not a fit: People under 18, pregnant individuals, those with severe cardiovascular disease, or those unable to give informed consent are excluded and would not benefit from participation.
Why it matters
Potential benefit: If successful, EIT could provide a painless bedside way to detect and monitor regional lung problems, especially for patients who cannot perform spirometry.
How similar studies have performed: Prior research and clinical use of EIT in critical care and ventilation monitoring have shown promise, but using EIT broadly for routine outpatient lung diagnosis remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years and older * Individuals diagnosed with any of the following lung diseases, as these are the primary focus of the study: Chronic obstructive pulmonary disease, Asthma, Pulmonary fibrosis, Pneumonia, Patients with a history of COVID-19 infection showing residual pulmonary findings. * Additionally, healthy subjects will be enrolled to obtain normal standard values (with normal physical examination and no respiratory symptoms, BMI 18-36 - cause EIT performance can be BMI dependent, Non-smokers or ex-smokers abstinent ≥12 months) * Ability to perform spirometry while seated, except for possible participants who are specifically part of a subgroup analysis where inability to perform spirometry is the condition which is studied. Signing of an informed consent that has been approved by the ethics committee Exclusion Criteria: * Patients under 18 years of age * Severe cardiovascular disease * Pregnancy * Inability to express consent * Acute respiratory infection: Except for those recovering from pneumonia or COVID-19 within the study focus, participants with current respiratory infections will be excluded to avoid confounding effects on lung function tests * Inability to perform spirometry
Where this trial is running
Olomouc
- Department of Pulmonary Diseases and Tuberculosis, University hospital Olomouc — Olomouc, Czechia (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.