Comparing PET/CT guided biopsy and CT guided biopsy for lung lesions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of PET/CT guided biopsy versus traditional CT guided biopsy in evaluating suspected lung neoplasms. The study will randomly assign participants to receive one of the two biopsy techniques, focusing on diagnostic yield, accuracy, and complications associated with each method. By utilizing functional imaging, the PET/CT guided biopsy may provide more accurate results by identifying areas with the highest concentration of neoplastic cells. This research addresses the limitations of CT guided biopsies, particularly in large lung lesions that can complicate diagnosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age above 18 years
* INR \< 1.2 and platelet counts \> 80,000/mm3
* CT thorax with lung lesion more than 10 mm.
* Accessible lesions for CT-guided biopsy.

Exclusion Criteria:

* Participants with pre-existing bleeding diathesis like hemophilia, coagulopathy defined by -INR ≥1.2 and Platelet counts ≤ 80,000/mm3
* Participants who refuse to provide consent
* Signs of hypoperfusion like hypotension, cyanosis etc.
* Presence of hypoxemia with SpO2 \< 94 %- measured in a pulse oximeter)
* Pregnant/Lactating female subjects
* Non-cooperative subjects
* Lesions that are inaccessible (decision made on pre-biopsy planning)
* Serum creatinine level more than 2mg/dl.

Where it's running

• All India Institute of Medical Sciences, Bhubaneswar
  Bhubaneswar, Odisha, India Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Electrical Impedance Tomography for Monitoring Lung Disease

  This test tries to see if a painless, noninvasive imaging method called electrical impedance tomography (EIT) can track how air is distributed in the lungs of adults with lung diseases and healthy volunteers and how those results match standard spirometry.

  Recruiting University Hospital Olomouc · Olomouc · NCT07356076

• Mosliciguat added to inhaled treprostinil for pulmonary hypertension from ILD

  This trial tests whether adding inhaled mosliciguat to your inhaled treprostinil is safe and tolerable for people with pulmonary hypertension caused by interstitial lung disease.

  Recruiting at 13 sites Phase 2 Pulmovant, Inc. · Santa Barbara, California and 12 other locations · NCT07333183

• Collecting lung sound recordings using Eko digital stethoscopes in clinic

  This project will try to teach computer programs to recognize wheeze, crackles, rhonchi, stridor, rales, and cough from stethoscope recordings in adults with suspected or diagnosed lung conditions and in people with normal lungs.

  Recruiting Eko Devices, Inc. · Mumbai, Maharashtra · NCT07270744

• Multi-omics prediction of graft problems after lung transplant

  We will test whether repeated blood and lung-fluid multi-omics tests can spot early graft dysfunction in adults after lung transplantation.

  Recruiting Shanghai Pulmonary Hospital, Shanghai, China · Shanghai · NCT07243964

• Recording lung sounds with Eko digital stethoscopes in clinic

  This project will test an AI that listens to lung sounds recorded with Eko digital stethoscopes to find abnormal sounds in people with or without lung disease.

  Recruiting at 2 sites Eko Devices, Inc. · Jacksonville, Florida and 1 other locations · NCT07227376

• Trop2- and EpCAM-targeted PET/CT to help distinguish non-small cell lung cancer

  This project will test whether PET/CT scans that target Trop2 and EpCAM can show protein expression in tumors of people with suspected non-small cell lung cancer.

  Recruiting RenJi Hospital · Shanghai · NCT07026110

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.