Comparing PET/CT guided biopsy and CT guided biopsy for lung lesions
PET/CT GUIDED BIOPSY VERSUS CT GUIDED BIOPSY IN EVALUATION OF SUSPECTED LUNG NEOPLASMS
This study is testing whether a PET/CT guided biopsy can provide better results than a traditional CT guided biopsy for people with suspected lung tumors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 108 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | All India Institute of Medical Sciences, Bhubaneswar Academic / other |
| Locations | 1 site (Bhubaneswar, Odisha) |
| Trial ID | NCT06923098 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of PET/CT guided biopsy versus traditional CT guided biopsy in evaluating suspected lung neoplasms. The study will randomly assign participants to receive one of the two biopsy techniques, focusing on diagnostic yield, accuracy, and complications associated with each method. By utilizing functional imaging, the PET/CT guided biopsy may provide more accurate results by identifying areas with the highest concentration of neoplastic cells. This research addresses the limitations of CT guided biopsies, particularly in large lung lesions that can complicate diagnosis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years with accessible lung lesions greater than 10 mm.
Not a fit: Patients with bleeding disorders, hypoperfusion, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of lung neoplasms, improving patient outcomes.
How similar studies have performed: While few studies have explored PET/CT guided biopsy, this approach is relatively novel and has not been extensively tested in comparison to CT guided biopsy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age above 18 years * INR \< 1.2 and platelet counts \> 80,000/mm3 * CT thorax with lung lesion more than 10 mm. * Accessible lesions for CT-guided biopsy. Exclusion Criteria: * Participants with pre-existing bleeding diathesis like hemophilia, coagulopathy defined by -INR ≥1.2 and Platelet counts ≤ 80,000/mm3 * Participants who refuse to provide consent * Signs of hypoperfusion like hypotension, cyanosis etc. * Presence of hypoxemia with SpO2 \< 94 %- measured in a pulse oximeter) * Pregnant/Lactating female subjects * Non-cooperative subjects * Lesions that are inaccessible (decision made on pre-biopsy planning) * Serum creatinine level more than 2mg/dl.
Where this trial is running
Bhubaneswar, Odisha
- All India Institute of Medical Sciences, Bhubaneswar — Bhubaneswar, Odisha, India (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.