Condition

Intensive Care Unit clinical trials and research

• 17Clinical trials
• 42NIH research projects
• 11Countries

Newest Intensive Care Unit clinical trials

All recruiting trials (17)

• Genomic changes of Klebsiella pneumoniae and Enterobacter cloacae in ICU patients over time

  This study tests how the gut bacteria Klebsiella pneumoniae and Enterobacter cloacae evolve over time in adults in ICUs.

  Recruiting University Hospital, Caen · Caen · NCT07744321

• Using blood cell ratios and procalcitonin to predict outcomes for adults with sepsis in the ICU

  This project will test whether routine blood measures—neutrophil-to-lymphocyte-and-platelet ratio, procalcitonin, and total white blood cell count—can help predict outcomes for adults with sepsis in the intensive care unit.

  Recruiting Ain Shams University · Cairo · NCT07200817

• Two eye care methods to prevent eye problems in ventilated ICU patients

  This tests whether using an eye care kit, a written eye-care protocol, or both will reduce eye complications compared with standard care in adults on mechanical ventilation in the ICU.

  Recruiting Istanbul Saglik Bilimleri University · Istanbul, Istanbul · NCT07070843

• Virtual reality to improve comfort for adults in the surgical ICU

  This trial will try immersive virtual reality (HypnoVR) sessions to reduce discomfort for adults who stay at least 48 hours in the surgical intensive care unit after major cardiothoracic or abdominal surgery.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06830369

• Calibration of esophageal balloon catheter for patients on mechanical ventilation

  This study is testing how to better calibrate a special balloon used in the esophagus to measure pressure in patients on mechanical ventilation, to see if it helps improve their care.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06584604

• Improving care for critically ill children in Asia

  This study is trying to improve care for critically ill children in Asian hospitals by collecting data to find out what helps or harms their recovery and using that information to create tools that predict their outcomes.

  Recruiting at 2 sites KK Women's and Children's Hospital · Singapore and 1 other locations · NCT06481644

• Predicting blockages in external ventricular drains for ICU patients

  This study is trying to find out which ICU patients with external ventricular drains are at higher risk for blockages after bleeding in the brain, to help improve their care.

  Recruiting Nantes University Hospital · Nantes, Loire-Atlantique · NCT06466811

• Comparing two dialysis techniques for kidney injury in ICU patients

  This study is testing whether a new dialysis method using citrate is just as good as a traditional method using heparin for helping ICU patients with kidney injury lower their urea levels.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06369064

• Using contrast-enhanced ultrasound to assess kidney function in ICU patients

  This study is testing whether a special type of ultrasound can help doctors understand kidney function better in ICU patients with acute kidney injury.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT06341062

• Measuring muscle strength in critically ill patients and healthy individuals in Brazil

  This study is trying to find out how strong muscles are in critically ill patients and healthy people in Brazil to help set standard measures for muscle strength.

  Recruiting at 3 sites University of Pernambuco · Recife, Brazil and 3 other locations · NCT06296381

• Using fish oil to improve recovery in high-risk cardiac surgery patients

  This study is testing if giving fish oil to high-risk heart surgery patients can help them recover better and reduce heart rhythm problems after surgery.

  Recruiting at 9 sites Phase 2 GCP-Service International West GmbH · Augsburg and 9 other locations · NCT06279793

• Managing alarm noise in intensive care units to improve patient safety

  This study is testing a new way to manage alarm sounds in intensive care units to see if it can make the environment safer and less stressful for patients and staff.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06175091

• Understanding patient experiences after severe seizures

  This study looks at the long-term experiences and challenges faced by people who have survived severe seizures to see how it affects their daily lives and well-being.

  Recruiting at 15 sites Versailles Hospital · Angoulême and 18 other locations · NCT06100978

• Validation of a device for monitoring vital signs in children

  This study is testing a new device called the VT-Patch® to see if it accurately measures vital signs like heart rate and temperature in children with different skin colors.

  Recruiting VitalTracer Ltd. · Montreal, Quebec · NCT05451875

• Evaluating the impact of diaries for ICU patients and their families

  This study is testing if giving diaries to ICU patients and their families helps improve their mental health and quality of life compared to standard care.

  Recruiting University of Barcelona · Barcelona · NCT05288140

• Understanding the immune response in COVID-19 patients in intensive care

  This study looks at how the immune system reacts in adults with severe COVID-19 who are in intensive care to help improve future treatments.

  Recruiting at 5 sites Hospices Civils de Lyon · Bron and 7 other locations · NCT04392401

• Serratus plane block to reduce pain during pleural drainage in the ICU.

  This study will test whether a serratus plane nerve block with lidocaine reduces pain for awake adults in the ICU who need pleural drainage.

  Recruiting Phase 3 Centre Hospitalier Universitaire, Amiens · Amiens · NCT03984656

NIH-funded research (newest 40 of 42)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Phthalate Exposure and How It Affects Newborns in the NICU

  This grant looks at how chemicals called phthalates in the NICU environment may affect the health and development of newborns, especially those born prematurely.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11594454

• Improving care for opioid use disorder in the ICU

  This project helps hospital staff in intensive care units provide better care for patients with opioid use disorder.

  NIH research Mainehealth · Portland, United States · NIH-11477142

• Juggling Work and Family for Parents of Very Preterm Babies

  A study to understand how work and family demands affect parents of very preterm infants and how this shapes their ability to support their baby’s development.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11413664

• Implementing SDOH screening and referrals in the NICU to support fragile newborns

  A NICU-based program to screen newborns and families for social needs and connect them to services that can improve health and development.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11398100

• Attenuating Depression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors

  A new online cognitive behavioral therapy program is being tested to help older ICU survivors who are experiencing depressive symptoms and may be at risk for cognitive decline.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11397007

• Multisensory care to boost development in preterm babies in the NICU

  A program called SENSE uses gentle touch, sounds, and parent bonding in the NICU to support brain development for very preterm infants and help families stay involved.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11378465

• Improving ICU family meetings: how communication quality affects outcomes

  This project studies how the way doctors and ICU teams talk with family members affects stress, satisfaction, and care for seriously ill patients.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11362176

• Supporting opioid use disorder care in the ICU with a clinician dashboard and education

  Aimed at improving how ICU teams in MaineHealth identify and treat opioid use disorder, using a clinician dashboard, tailored education, and language processing to standardize care.

  NIH research Mainehealth · Portland, United States · NIH-11334491

• Early warning monitors for very small premature babies in the NICU

  Uses advanced computer analysis of bedside monitor data to find early signs of infection and serious gut disease in very low birth weight premature infants.

  NIH research University of Virginia · Charlottesville, United States · NIH-11327642

• Improving mobile photon-counting CT scans for brain patients in the neuro ICU

  Aiming to make bedside brain CT images from a mobile scanner clearer using deep learning, so doctors can diagnose faster without moving the patient.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11326200

• Engaging family caregivers in ICU care with FamilyRoom.Health

  A program tests a patient-facing digital platform that helps family caregivers participate more effectively in ICU care.

  NIH research Family Room LLC · Lincoln, United States · NIH-11313259

• Tailoring blood pressure to protect brain blood flow during and after heart surgery

  Aims to see if monitoring each person's brain blood-flow limits and personalizing blood-pressure targets during and after heart surgery reduces delirium and longer-term memory and thinking problems.

  NIH research Stanford University · Stanford, United States · NIH-11310140

• Virtual family-centered rounds to improve care and family well-being in the PICU

  A family-focused telehealth approach is tested to help caregivers participate in rounds and improve care and psychosocial outcomes for kids in the PICU.

  NIH research University of California at Davis · Davis, United States · NIH-11296759

• Understanding how sepsis affects recovery in children after intensive care

  This study is looking at how sepsis affects kids' physical abilities over time after they've been treated in the PICU, to help us understand their recovery better and improve care for future patients.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11195327

• Balancing work and family after a NICU stay

  This project follows parents of very preterm infants to understand how they manage returning to work and caring for their baby, with special attention to Black and low-income families.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11194267

• How NICU light and noise affect early brain and hearing development

  This work looks at whether bright lights and loud sounds like those in the NICU can change early brain and hearing development relevant to infants born prematurely.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11190849

• Helping preterm babies in the NICU grow and develop better with gentle sensory experiences

  This project aims to help very preterm babies in the NICU develop well by providing them with gentle, positive sensory experiences and supporting their parents.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11169838

• Screening and support for families' social needs in the NICU

  This project brings routine screening for housing, food, and other social needs to parents of preterm babies in the neonatal intensive care unit and connects families to community services.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11168947

• Internet CBT to reduce depression and memory decline after an ICU stay

  This project offers online cognitive behavioral therapy to help reduce depression and slow thinking and memory problems in older adults who survived an intensive care unit stay.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11166462

• Improving image quality of mobile CT scans for brain care in intensive care units

  This study is working on making the pictures from mobile CT scanners used in neuro intensive care units clearer and more accurate, so doctors can better diagnose serious conditions like strokes and bleeding in patients without having to move them around.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11121759

• Understanding how NICU room changes affect babies and families

  This project looks at how changing NICU rooms from open spaces to private family rooms affects the health of babies and the experiences of their families, especially focusing on differences among various racial and income groups.

  NIH research North Carolina Agri & Tech St Univ · Greensboro, United States · NIH-11099964

• Understanding barriers to family engagement in neonatal intensive care units

  This study is looking at the difficulties that low-income families face when trying to connect with their premature babies in the NICU, like issues with transportation and language, to find ways to help them be more involved and improve their babies' health.

  NIH research Stanford University · Stanford, United States · NIH-11093465

• Improving family communication in the ICU and its effect on health

  This project looks at how well healthcare teams talk with family members in the intensive care unit and how that communication affects family well-being and patient care.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11090453

• Helping patients with acute brain injuries and their caregivers build resilience together

  This study is for patients who have had a brain injury, like a stroke, and their caregivers, and it offers a friendly program called 'Recovering Together' to help them cope with stress and support each other while they heal in the hospital.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11090444

• Understanding how sleep affects delirium in ICU patients

  This study is looking at how sleep patterns might affect older adults who are in the ICU after thoracic surgery, to see if poor sleep could lead to confusion or delirium during their hospital stay, with the goal of finding ways to help them feel better.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11087537

• Improving how intensive care units are staffed in the U.S.

  This study is looking at how to make intensive care units (ICUs) better for patients with serious breathing problems by figuring out the best ways to organize staff and teams, so that doctors can provide the best care possible.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11063832

• A virtual reality application to reduce delirium in ICU patients.

  This study is testing a virtual reality program that helps ICU patients stay mentally active, sleep better, and move around more, all to prevent confusion and improve their recovery, while making it easier for nurses to provide care.

  NIH research Ralphvr INC. · Lexington, United States · NIH-11007082

• Using online therapy to help older ICU survivors with depression and cognitive decline

  This study is looking at whether online therapy can help older adults who have been in intensive care feel better mentally and improve their thinking skills, especially focusing on those from different backgrounds.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10999495

• Exploring the challenges faced by parents of premature infants in balancing work and family life

  This study is looking at how parents of premature babies in the NICU manage their work and family life, especially focusing on the challenges faced by diverse families, like those from Black and low-income backgrounds, to help improve support for them and their babies.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-10923547

• Understanding how sepsis affects recovery in children after intensive care

  This study is looking at how sepsis affects kids' bodies over time after they've been treated in the hospital, to find ways to help them recover better and live healthier lives.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-10899755

• Improving health outcomes for preterm infants by addressing social factors

  This study is looking at how to help families with premature babies in the NICU by checking in on their needs, like housing and jobs, so they can get the support they need while their little ones are in the hospital.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-10899635

• Improving care for preterm infants in the neonatal intensive care unit

  This study is testing a special program called SENSE to help preterm babies in the NICU grow and develop better by using gentle touch, sounds, and skin-to-skin time, while also helping parents connect with their little ones during their hospital stay.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10892638

• Understanding brain blood flow and its effects on recovery after heart surgery

  This study is looking at how blood flow to the brain after heart surgery can affect your thinking and memory, and it aims to find the best ways to manage your blood pressure during recovery to help prevent problems like confusion and memory loss.

  NIH research Stanford University · Stanford, United States · NIH-10883892

• Improving cleanliness in ICUs to reduce antibiotic-resistant infections

  This study is looking at how to make intensive care units cleaner to help protect patients from infections caused by antibiotic-resistant germs, by figuring out where these germs are most commonly found and how they spread.

  NIH research Washington University · Saint Louis, United States · NIH-10873210

• Effects of light and sound exposure on brain development in premature infants

  This study is looking at how light and sound in a neonatal intensive care unit might affect the brain development of premature babies, using gerbils to mimic their experience, so we can better understand how these factors could impact their hearing and vision as they grow.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-10864443

• Testing different doses of epinephrine for treating low blood pressure in children in the ICU

  This study is looking at how two different amounts of epinephrine can help raise blood pressure in kids who are very sick and have low blood pressure in the ICU, to find out which dose works best to keep them safe.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10848428

• Evaluating driving safety in older adults recovering from critical illness

  This study is looking at how serious illnesses can affect older adults' driving skills, and it aims to create helpful tools to keep them safe on the road while also improving their overall well-being after their hospital stay.

  NIH research Baylor Research Institute · Dallas, United States · NIH-10813218

• Using AI to improve decision-making in intensive care units

  This study is working on new tools that use artificial intelligence to help doctors and nurses in intensive care units keep a closer eye on patients by looking at things like facial expressions and movements, so they can make better decisions and help patients more quickly.

  NIH research University of Florida · Gainesville, United States · NIH-10769812

• Investigating the effects of phthalate exposure on premature infants in the NICU

  This study is looking at how certain chemicals found in hospitals might affect the health and development of premature babies in NICUs, with the hope of finding ways to keep these little ones safer and healthier.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-10736301

• Creating a tool to help families make decisions about tracheostomy in the ICU

  This study is working to make it easier for families to make decisions about tracheostomy procedures in the ICU by creating a helpful tool that addresses their specific questions and worries.

  NIH research Denver Health and Hospital Authority · Denver, United States · NIH-10657564

Related topics

Quick answers

How many Intensive Care Unit clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in France (8 trials), Spain (1 trial), Egypt (1 trial), Singapore (1 trial), Thailand (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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