Condition

Cardiopulmonary Bypass clinical trials and research

• 19Clinical trials
• 10NIH research projects
• 1New in 30 days
• 13Countries

Newest Cardiopulmonary Bypass clinical trials

All recruiting trials (19)

• Optimized Flow for Obese Patients Undergoing Heart Surgery

  In this study, researchers will test whether using ideal body weight to set cardiopulmonary bypass flow during heart surgery helps obese adults see fewer transfusions and related complications.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07917494

• Integrated intraoperative hemodynamic monitoring during cardiac surgery with CPB

  This pilot study tests a single-dashboard monitoring system to see if it can capture heart and tissue perfusion data during elective cardiac surgery with bypass in adults without changing patient care.

  Recruiting Hernán Darío Castro Arias MD MSc · Medellín, Antioquia · NCT07683299

• Preventive Narrative Exposure for PTSD After Cardiac Surgery in the ICU

  In adults having cardiopulmonary bypass heart surgery, this trial tests whether an ICU-based narrative exposure intervention helps prevent posttraumatic stress symptoms compared with standard care.

  Recruiting First Affiliated Hospital of Fujian Medical University · Fuzhou, Fujian · NCT07632131

• Impact of cardiopulmonary bypass on platelet lipids and bleeding after cardiac surgery

  This study tests how CPB changes platelet lipid metabolism and procoagulant platelets to see if these changes relate to inflammation and bleeding after cardiac surgery.

  Recruiting Université Catholique de Louvain · Brussels · NCT07630987

• Transcutaneous auricular vagus nerve stimulation to prevent kidney injury after heart surgery

  This trial tests whether applying a non-invasive ear stimulation (taVNS) around the time of elective heart surgery can help prevent acute kidney injury in adults undergoing cardiopulmonary bypass.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07549243

• Femorofemoral versus left‑heart bypass for open thoracoabdominal aortic aneurysm repair

  This will test whether femorofemoral bypass or left‑heart bypass works better for adults having open repair of a thoracoabdominal aortic aneurysm.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT07518251

• Global longitudinal strain to predict difficult separation from cardiopulmonary bypass

  This will test whether a heart ultrasound measure called global longitudinal strain (GLS) can predict which adults having elective cardiac surgery will have trouble coming off cardiopulmonary bypass.

  Recruiting at 2 sites Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Rome and 1 other locations · NCT07390903

• Eurosets arterial and venous cannulas for cardiopulmonary bypass procedures

  This trial will test Eurosets arterial and venous cannulas during cardiopulmonary bypass in adults having elective coronary or aortic valve surgery to see if they are as safe and work as well as Medtronic cannulas.

  Recruiting Eurosets S.r.l. · Bari, BA · NCT07354841

• How the heart-lung machine priming fluid affects blood chemistry during heart surgery

  This trial will test whether different priming fluids used to fill the heart-lung machine change acid-base balance, electrolytes, and osmolality in adults having isolated CABG or aortic valve replacement.

  Recruiting Region Skane · Lund · NCT07267546

• Personalized lung volume optimization with PEEP titration for children after heart surgery or with severe respiratory failure

  This trial tests whether a personalized lung volume optimization maneuver using PEEP titration can improve heart and lung function in children after cardiopulmonary bypass surgery or in those with severe respiratory failure at risk for ECMO.

  Recruiting Phase 1/2 Charite University, Berlin, Germany · Tübingen · NCT07193719

• Milrinone vs Epinephrine on TAPSE after cardiopulmonary bypass

  This study tests whether milrinone or epinephrine better supports right ventricular function (TAPSE) after cardiac surgery with CPB in adults.

  Recruiting Mansoura University · Al Mansurah · NCT07144267

• Autologous Cold-Stored Platelets for Complex Cardiac Surgery

  This study tests whether using a patient’s own cold-stored platelets, donated 7–10 days before surgery, improves outcomes for adults undergoing complex cardiac procedures compared with standard allogeneic platelets.

  Recruiting Phase 2/3 University Health Network, Toronto · Toronto, Ontario · NCT07064954

• Comparing two pain management techniques for children undergoing heart surgery

  This study is testing which of two pain management techniques works better for children having heart surgery to help them recover faster and feel less pain.

  Recruiting Cairo University · Cairo · NCT06984276

• Using methylprednisolone to prevent kidney injury during heart surgery

  This study is testing if giving a single dose of methylprednisolone during heart surgery can help prevent kidney injury after the operation.

  Recruiting Phase 1 Ain Shams University · Cairo, Abbasia · NCT06917859

• Using Nitric Oxide to Improve Recovery in Heart Surgery

  This study tests if inhaling nitric oxide during heart surgery can help adults recover better and avoid complications like kidney problems and breathing issues.

  Recruiting Phase 3 Xijing Hospital · Boston, Massachusetts and 2 other locations · NCT06702553

• Using fish oil to improve recovery in high-risk cardiac surgery patients

  This study is testing if giving fish oil to high-risk heart surgery patients can help them recover better and reduce heart rhythm problems after surgery.

  Recruiting at 9 sites Phase 2 GCP-Service International West GmbH · Augsburg and 9 other locations · NCT06279793

• Effect of Tranexamic Acid on Bleeding in Cardiac Surgery

  This study is testing how different doses of tranexamic acid can help reduce bleeding and the need for blood transfusions in adults having heart surgery.

  Recruiting at 2 sites Phase 4 Taichung Veterans General Hospital · Taichung and 1 other locations · NCT06109155

• Understanding lung injury in young patients after heart surgery

  This study looks at how heart surgery can cause lung injury in young patients by examining the role of certain immune cells to help improve their recovery.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04296071

• Optimizing blood flow and anticoagulation for obese patients in heart surgery

  This study is testing if using a patient's lean body mass to guide blood flow and medication during heart surgery can help obese patients have better outcomes and fewer complications.

  Recruiting Laval University · Québec, Quebec · NCT03302195

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Gut bacteria and increased inflammation after heart bypass in children with congenital heart defects

  This project will look at whether an unhealthy gut microbiome in children with congenital heart defects makes inflammation and gut barrier damage worse after cardiopulmonary bypass surgery.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11362104

• How red blood cells drive inflammation after heart bypass in children

  Looking at whether damaged red blood cells make the inflammation and organ problems children often get after heart bypass surgery worse.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11311851

• Why heart–lung bypass causes inflammation in newborns

  Seeing if the high blood-flow stresses during heart–lung bypass trigger inflammation in babies having open‑heart surgery.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11289425

• A protein treatment to protect babies' hearts during heart surgery

  A protein medicine called OMX aims to deliver oxygen to protect the hearts and organs of newborns and infants during cardiopulmonary bypass surgery.

  NIH research Omniox, INC. · San Francisco, UNITED STATES · NIH-11167638

• How red blood cells affect inflammation during heart surgery in children

  This study is looking at how red blood cells might cause inflammation during heart surgeries in kids, with the goal of finding ways to reduce this inflammation and help patients recover better after surgery.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11075884

• Effects of exosomes on heart injury during heart surgery

  This study is looking at how tiny particles called exosomes, which come from your cells, might influence heart damage during heart surgery for mitral regurgitation, helping doctors better understand and predict how your heart will recover after the procedure.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-11043303

• Understanding how heart-lung machines affect inflammation in children during surgery

  This study is looking at how a heart-lung machine used during heart surgery for kids can cause inflammation in their bodies, and it aims to find ways to reduce this inflammation to help them recover better after surgery.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11035150

• Improving heart surgery outcomes by optimizing blood flow during surgery

  This study is looking at how changing the way blood flows during heart surgery might help protect your kidneys and lower the chances of kidney problems afterward, so you can recover better after your operation.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10909850

• Comparing heart surgery methods to protect brain health

  This study is looking at how two different heart surgery methods might affect brain health in kids with congenital heart diseases, to see which one helps protect their brain better during surgery.

  NIH research Stanford University · Stanford, United States · NIH-10773170

• Understanding how cell-free hemoglobin affects kidney injury after heart surgery in children

  This study is looking at how a substance called cell-free plasma hemoglobin, which can be released during heart surgeries in kids, might lead to kidney problems, and it aims to find ways to help protect their kidneys during these procedures.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10654592

Related topics

Quick answers

How many Cardiopulmonary Bypass clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (4 trials), Egypt (3 trials), Italy (2 trials), Canada (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2/3: 1, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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