Testing different doses of epinephrine for treating low blood pressure in children in the ICU
Official title: Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
Funded at Boston Children's Hospital · NIH-10848428 · Data updated 2026-11-12
This study is looking at how two different amounts of epinephrine can help raise blood pressure in kids who are very sick and have low blood pressure in the ICU, to find out which dose works best to keep them safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $193,871 |
| NIH project number | 5K23HL148312-05 |
| Project ID | NIH-10848428 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients aged 0-11 years who are admitted to the intensive care unit with acute hypotension.
✕Less likely to help
Patients who are not experiencing acute hypotension or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates the effects of two different doses of epinephrine on blood pressure in pediatric patients experiencing acute hypotension in the intensive care unit. The study will randomly assign children to receive either 0.5 mcg/kg or 1 mcg/kg of diluted epinephrine, and their blood pressure will be monitored before and after treatment. By comparing the hemodynamic responses between the two groups, the research aims to identify the most effective dose for improving blood pressure and potentially preventing cardiac arrest. This trial is crucial as it addresses a common yet serious condition in critically ill children, where timely intervention can significantly impact outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for managing low blood pressure in critically ill children, potentially reducing mortality and long-term neurological damage.
How similar studies have gone: While the use of epinephrine in pediatric emergencies is common, this specific dose-effect trial is novel and aims to fill a significant gap in the existing literature.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Ross, Catherine — Boston Children's Hospital
- Study coordinator: Ross, Catherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.