Condition

Hip Osteoarthritis clinical trials and research

• 41Clinical trials
• 5NIH research projects
• 13Countries

Newest Hip Osteoarthritis clinical trials

All recruiting trials (41)

• Ceramic hip resurfacing vs total hip arthroplasty for hip OA

  This trial tests whether ceramic hip resurfacing helps people with hip OA walk farther each day than a modern total hip replacement.

  Recruiting Danderyd Hospital · Danderyd · NCT07839403

• Dexmedetomidine during hip replacement to modulate nerves and inflammation

  A randomized, placebo-controlled study tests whether intravenous dexmedetomidine given during spinal anesthesia with a PENG nerve block can help regulate the body's stress and inflammatory response and improve recovery after hip replacement.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07743853

• Preoperative Fasting to Shape the Gut with Hip Replacement

  This trial tests whether a 20-day preoperative fasting plan can lower inflammatory signals and broaden gut microbes in adults undergoing total hip arthroplasty.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07651462

• Cryoneurolysis for Chronic Pain: 6- and 12-Month Outcomes in Routine Care

  This study tests whether cryoneurolysis, done as part of standard care for people with chronic pain, leads to meaningful improvements over 6 to 12 months.

  Recruiting Yale University · Old Saybrook, Connecticut · NCT07639060

• Spinal anesthesia with intrathecal morphine vs PENG block (with or without dexamethasone) for hip replacement

  In people aged 60 and older undergoing total hip arthroplasty, this study tests whether three anesthesia approaches provide better pain control and fewer side effects: spinal with intrathecal morphine, spinal with a PENG block, or spinal with a PENG block plus dexamethasone.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07584200

• Intravenous dexamethasone for better pain control after hip replacement with a PENG block

  This study tests whether giving dexamethasone through a vein, in 0, 4, or 8 mg doses, helps control pain after total hip arthroplasty when used with a PENG block.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07581470

• PENG Block added to spinal anesthesia for hip replacement in older adults

  This study tests whether adding a PENG block to spinal anesthesia can lower delirium after hip replacement in people 75 and older.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07449468

• Rare metals and immune markers in hip and knee tissue from patients having joint replacement

  This project will see if levels of rare metals, trace elements, and certain immune markers are low in the joint tissue and blood of adults having hip or knee replacement for osteoarthritis.

  Recruiting Medical University of Warsaw · Ostrów Mazowiecka, Masovian Voivodeship · NCT07347821

• Trigger-point steroid injections versus hip joint steroid injections for hip osteoarthritis

  This test compares steroid injections into myofascial trigger points versus injections into the hip joint to see which reduces pain and improves function in people aged 45 and older with hip osteoarthritis.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07347041

• PENG nerve block with different steroid and sedative combinations for hip surgery in adults 65 and older

  This trial will see if adding different combinations of dexamethasone and dexmedetomidine to a PENG nerve block gives adults 65 and older longer and better pain relief after hip surgery.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07327931

• PENG Block or Periarticular Injection for Hip Surgery in Older Adults

  This study tests three pain-relief approaches after hip surgery in adults 65 and older to see which best eases pain while keeping movement safe.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07327892

• PENG nerve block plus dexmedetomidine for hip surgery pain in older adults

  This will test whether adding a small dose of dexmedetomidine to a PENG nerve block gives longer, better pain relief and reduces opioid need for people 65 and older having hip surgery.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07327372

• Clinical and radiographic outcomes after a fixed‑polyethylene posteriorly stabilized cemented total knee replacement with at least one‑year follow‑up

  This project tests how well a specific fixed‑polyethylene posteriorly stabilized cemented total knee replacement performs in adults who had the operation, using clinical and x‑ray data at least one year after surgery.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07313449

• Comparing three motor-sparing nerve blocks for pain after hip replacement

  This trial will test whether the PENG block, suprainguinal FICB, or lumbar ESPB provides the best pain relief while preserving leg strength after hip arthroplasty in adults 65 and older.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07288983

• App-based outcome score for knee and hip replacement patients

  This project will test a smartphone app that combines movement tracking and questionnaires to try to predict recovery and long-term outcomes for adults who have or will have knee or hip replacement.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT07212699

• PENG block versus combined lumbar and sacral erector spinae plane (ESP) blocks for pain after total hip replacement

  This trial will test whether the PENG nerve block or a combined lumbar-plus-sacral ESP block gives better pain relief and reduces opioid use in adults aged 65 and older having elective total hip replacement.

  Recruiting Phase 4 Poznan University of Medical Sciences · Poznan · NCT07180979

• Combining ultrasound-guided hyaluronic acid injections, high-power laser therapy, and rehabilitation for hip osteoarthritis

  This trial will test whether adding high-power laser therapy to ultrasound-guided hyaluronic acid injections and physiotherapy improves pain and hip function in adults with stage 1–3 hip osteoarthritis and BMI under 30.

  Recruiting at 2 sites University of Catanzaro · Catanzaro, CZ and 1 other locations · NCT07108400

• Three-week intensive rehabilitation for people with ongoing problems after total hip or knee replacement.

  This program tests whether three weeks of intensive rehabilitation helps people who continue to have physical problems after total hip or knee replacement.

  Recruiting Horsens Hospital · Brædstrup · NCT07105657

• Z1 Hip System post-market follow-up

  This tests whether the Z1 Femoral Hip System is safe and helpful for adults having total or hemi hip replacement for osteoarthritis, femoral head/neck fractures, or avascular necrosis.

  Recruiting at 5 sites Zimmer Biomet · Platte City, Missouri and 4 other locations · NCT07104279

• Povidone-iodine versus chlorhexidine wound wash after total hip replacement

  We will test whether washing the surgical wound with povidone-iodine or chlorhexidine helps wounds heal better after total hip replacement in people with hip osteoarthritis or avascular necrosis of the femoral head.

  Recruiting at 2 sites University of Pittsburgh · Monroeville, Pennsylvania and 1 other locations · NCT07104084

• ReDI-2: Virtual home-based rehabilitation for hip and knee osteoarthritis

  This project will test whether 12 weeks of one-on-one or small-group virtual physical therapy helps rural Albertans with hip or knee osteoarthritis manage their condition better than usual care.

  Recruiting University of Alberta · Edmonton, Alberta · NCT07055113

• Comparing platelet rich plasma and corticosteroids for hip osteoarthritis pain relief

  This study is testing whether platelet rich plasma injections work better than corticosteroid injections to relieve pain and improve function in people with hip osteoarthritis.

  Recruiting Phase 4 LifeBridge Health · Baltimore, Maryland · NCT06793982

• Comparing general and spinal anesthesia for joint replacement surgery

  This study is testing whether using general or spinal anesthesia for hip or knee replacement surgery leads to better recovery experiences for patients.

  Recruiting University of Miami · Miami, Florida · NCT06747494

• Assessing the performance of a specific hip implant in patients needing hip replacement

  This study tests how well a new hip implant works for people with severe hip pain who need a hip replacement.

  Recruiting Medacta International SA · Saint-Jean · NCT06640764

• Evaluation of 3D Digital Surgery in Traumatology

  This study is testing if using 3D digital surgery tools can help patients with orthopedic conditions have better surgery outcomes and fewer complications compared to traditional methods.

  Recruiting Corporacion Parc Tauli · Sabadell, Barcelona · NCT06603831

• Evaluating hip approaches and navigation in total hip replacement for leg length discrepancies

  This study is testing different surgical methods for hip replacement to see which one helps patients with leg length differences feel better and have better results after surgery.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06506201

• Effects of education and exercise on hip osteoarthritis outcomes

  This study is testing if combining exercise with education can help people with hip osteoarthritis feel better and improve their joint health.

  Recruiting University of Aarhus · Aarhus C and 1 other locations · NCT06391554

• Evaluation of the DELTA Revision acetabular cup in hip arthroplasty

  This study is testing how well the DELTA Revision acetabular cup works for people with hip osteoarthritis who have had hip replacement surgery.

  Recruiting Limacorporate S.p.a · Otwock · NCT06359301

• Comparing radiofrequency treatment and corticosteroid injection for hip osteoarthritis pain

  This study is testing whether a new radiofrequency treatment works better than a steroid injection for relieving pain and improving movement in people with hip osteoarthritis.

  Recruiting University of Brasilia · Brasília, Federal District · NCT06221709

• Measuring Emphasys hip implant movement with radiostereometric analysis

  This project will test how much the Emphasys hip shell and stem move during the first two years after a primary hip replacement in people with hip osteoarthritis or similar conditions.

  Recruiting Canadian Radiostereometric Analysis Network · Winnipeg, Manitoba · NCT06173713

• Comparing two methods for hip pain relief after surgery

  This study is testing two different ways to relieve hip pain after surgery to see which one helps patients feel better without affecting their ability to move.

  Recruiting University of Chile · Santiago, Santiago Metropolitan · NCT06075004

• Understanding the impact of wait times on hip and knee replacement patients

  This study looks at how wait times for hip and knee replacements affect patients' health and recovery to help create better care plans for them.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06074900

• Investigating golfers' return to the sport after joint replacement surgery

  This study looks at how well golfers can return to playing after having hip, knee, or shoulder surgery to see how their recovery goes over the first year.

  Recruiting at 2 sites Hospital for Special Surgery, New York · New York, New York and 1 other locations · NCT05675618

• Evaluating a new surgical irrigation method for joint replacement surgeries

  This study is testing a new way to clean the surgical area during knee or hip replacement surgeries to see if it can lower the risk of infections compared to the usual method.

  Recruiting at 8 sites Ottawa Hospital Research Institute · Vancouver, British Columbia and 7 other locations · NCT05543941

• Comparing two types of PRP injections for hip osteoarthritis treatment

  This study is testing whether two different types of PRP injections can help people with hip osteoarthritis feel better over a year.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT05497349

• Comparing surgical approaches for hip surgery and their impact on limping

  This study is testing whether using a lateral or posterior surgical approach for hip replacement surgery affects the chances of patients having a limp one year later.

  Recruiting Sahlgrenska University Hospital · Mölndal · NCT05216666

• A program to help frail elderly patients prepare for hip and knee replacement surgery

  This study is testing a new program to help frail older adults get ready for hip or knee replacement surgery to see if it can improve their recovery after the operation.

  Recruiting McMaster University · Calgary, Alberta and 3 other locations · NCT05100966

• Bone marrow concentrate vs steroid shot for hip osteoarthritis

  In people with hip osteoarthritis, researchers test whether a bone marrow aspirate concentrate injection works differently from a Triamcinolone steroid injection to relieve pain and improve function.

  Recruiting Phase 3 The Cleveland Clinic · Weston, Florida · NCT04990128

• Collecting patient-reported outcomes after hip and knee surgeries

  This study is collecting feedback from people who have had hip or knee surgeries to see how well they are doing and how satisfied they are after their operations.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan · NCT04960098

• Comparing two nerve blocks for pain management after hip replacement surgery

  This study is testing which of two types of nerve blocks helps adults feel less pain after hip replacement surgery.

  Recruiting Phase 4 LifeBridge Health · Baltimore, Maryland · NCT04729686

• Evaluating the MobileLink Hip Prosthesis System Outcomes

  This study is looking at how well the MobileLink hip replacement system works and how satisfied patients are after getting it.

  Recruiting at 2 sites Waldemar Link GmbH & Co. KG · Kiel and 1 other locations · NCT04688593

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding hip osteoarthritis risk from hip shapes and genetics

  Researchers will look at how the shape of the hip and genetics influence the chances of developing hip OA and needing joint replacement, using AI to study large patient data.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11424533

• DNMT3A as a Target to Protect Hip Joints in Osteoarthritis

  A patient-friendly study aims to see if turning down a specific gene pathway can slow cartilage damage in people with femoroacetabular impingement and early hip OA.

  NIH research Washington University · Saint Louis, United States · NIH-11346619

• Bone-anchored (osseointegrated) prostheses and hip arthritis after above-knee amputation

  This project compares bone-anchored (osseointegrated) prostheses with traditional socket prostheses to understand their effects on hip arthritis in people with transfemoral (above-knee) amputations.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11241963

• Impact of bone-anchored prostheses on hip arthritis in amputees

  This study is looking at how different types of leg prosthetics, one that connects directly to the bone and another that uses a socket, might affect the health of your hip joint if you've lost a leg, to help find better options for amputees.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11000851

• Understanding how hip muscle problems affect exercise in people with hip osteoarthritis

  This study is looking at how problems with hip muscles affect exercise for people with hip osteoarthritis, so we can help create better workout plans that make it easier for you to stay active and feel better.

  NIH research University of Kentucky · Lexington, United States · NIH-10873837

Related topics

Quick answers

How many Hip Osteoarthritis clinical trials are recruiting right now?

41, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in Poland (11 trials), United States (8 trials), Canada (5 trials), Italy (4 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →