Impact of bone-anchored prostheses on hip arthritis in amputees
Official title: Effect of Osseointegrated Prostheses on the Pathogenesis of Hip Osteoarthritis in Patients with Lower Limb Loss
Funded at University of Colorado Denver · NIH-11000851 · Data updated 2026-11-12
This study is looking at how different types of leg prosthetics, one that connects directly to the bone and another that uses a socket, might affect the health of your hip joint if you've lost a leg, to help find better options for amputees.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | March 3, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $131,625 |
| NIH project number | 5K01AR080776-03 |
| Project ID | NIH-11000851 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone transfemoral amputation and are using or considering osseointegrated prostheses.
✕Less likely to help
Patients who have not undergone lower limb amputation or those using traditional socket prostheses without interest in osseointegration may not benefit from this research.
What this research studies
This research investigates how transfemoral osseointegrated prostheses, which are directly attached to the bone, may affect the development of hip osteoarthritis in patients who have lost a lower limb. The study will compare patients using these prostheses to those using traditional socket prostheses, focusing on how the different methods of load transmission impact hip joint health. By using advanced imaging techniques, the research aims to assess muscle quality and changes over time, providing insights into the relationship between prosthetic design and joint health. The findings could lead to improved prosthetic options and better outcomes for amputees.
Why it matters
Potential benefit: If successful, this research could lead to better prosthetic designs that reduce the risk of hip osteoarthritis in amputees.
How similar studies have gone: While the use of osseointegrated prostheses is gaining traction, this specific investigation into their impact on hip osteoarthritis is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Gaffney, Brecca — University of Colorado Denver
- Study coordinator: Gaffney, Brecca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.