Condition

Knee Osteoarthristis clinical trials and research

• 30Clinical trials
• 2New in 30 days
• 15Countries

Newest Knee Osteoarthristis clinical trials

All recruiting trials (30)

• NPT Feasibility in Knee Osteoarthritis

  This study tests whether NRPT can be safely given to adults with knee osteoarthritis and whether it shows early signals of benefit.

  Recruiting University of California, San Diego · San Diego, California · NCT07917403

• Aquatic exercise for knee osteoarthritis and central sensitization

  A water-based exercise program is being tested to see if it helps people aged 40–65 with knee osteoarthritis who also have central sensitization.

  Recruiting Kirsehir Ahi Evran Universitesi · Kırşehir, Merkez · NCT07883824

• Gender-based test of a graded weight-bearing physiotherapy for knee osteoarthritis

  We’re testing a 6-week, sensory-modulated graded weight-bearing physiotherapy to see if outcomes differ between men and women with knee osteoarthritis.

  Recruiting Shifa Tameer-e-Millat University · Gujar Khan, Punjab Province · NCT07784998

• Does implant type affect knee alignment when using KUNWU robotic surgery

  This trial tests whether two knee implants (Attune vs Persona) used with the KUNWU robotic system result in more accurate knee alignment after total knee replacement.

  Recruiting The University of Hong Kong · Hong Kong, Sandy Bay · NCT07777757

• Outpatient physiotherapy vs. mHealth exercise and self-management for knee osteoarthritis

  This study tests whether a mobile app–guided, self-managed knee OA exercise program is as good as traditional hospital-based therapy for improving walking speed in adults with knee OA.

  Recruiting Singapore General Hospital · Singapore · NCT07767409

• Digital Rehab Program for knee OA using multisensory gear and digital twin tech

  A digital rehabilitation program with a smart knee brace and real-time feedback is tested to help adults with knee OA improve movement and function at home.

  Recruiting National Taiwan University Hospital · Taipei and 2 other locations · NCT07695168

• Wearable exosuit to help people with knee osteoarthritis move more

  This study tests a wearable exoskeleton (Dephy Exoboot) to see if it helps adults with knee osteoarthritis walk more and reduce pain.

  Recruiting Massachusetts Institute of Technology · Cambridge, Massachusetts · NCT07652437

• Blood flow restriction training for knee osteoarthritis

  A personalized program using blood flow restriction and standard care to see if it helps adults with knee osteoarthritis.

  Recruiting University of Hail · Ha'il, Ha'il Region · NCT07590323

• Platelet-Rich Plasma from Two Different Systems in Knee Osteoarthritis

  This study compares PRP made by two FDA-approved machines to see if the platelets differ and whether injections help knee symptoms.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07491367

• Close vs. Open chain exercises with blood flow restriction for knee osteoarthritis

  This trial tests whether close-chain exercises with blood flow restriction or open-chain exercises with blood flow restriction help reduce knee pain and improve motion, strength, and function in adults with knee osteoarthritis.

  Recruiting Riphah International University · Rawalpindi and 1 other locations · NCT07426549

• Validity and reliability of the OMERACT knee ultrasound score in Turkish adults with knee osteoarthritis

  This project will test whether the OMERACT ultrasound scoring system works well for Turkish adults aged 45 and older who have knee osteoarthritis.

  Recruiting Izmir Democracy University · Izmir, İzmir · NCT07416357

• Diagonal PNF exercises versus conventional strength training for knee osteoarthritis pain and function

  This project will test whether diagonal PNF pattern exercises reduce pain and improve function in people aged 40–60 with knee osteoarthritis.

  Recruiting at 2 sites University of Karachi · Karachi, Sindh and 1 other locations · NCT07396233

• Genicular artery embolization for knee osteoarthritis — patient registry

  This registry will try genicular artery embolization (GAE) in adults with knee osteoarthritis whose pain hasn't improved with medicines to see if it reduces pain and improves quality of life over months to years.

  Recruiting Joint & Vascular Institute · Libertyville, Illinois · NCT07380906

• Neuropathic pain and its effect on pain level and function in knee osteoarthritis.

  This project will see how common neuropathic pain is and how it affects pain and daily function in people with knee osteoarthritis.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul · NCT07367126

• Hemi-tibial plateau osteotomy versus high tibial osteotomy with arthroscopic medial meniscus posterior root repair

  This study tests whether a newer hemi-tibial plateau osteotomy plus arthroscopic meniscus repair helps people with varus-aligned knees and medial meniscus posterior root tears improve more than the standard high tibial osteotomy plus repair.

  Recruiting Eighth Affiliated Hospital, Sun Yat-sen University · Shenzhen, Guangdong · NCT07356674

• Rare metals and immune markers in hip and knee tissue from patients having joint replacement

  This project will see if levels of rare metals, trace elements, and certain immune markers are low in the joint tissue and blood of adults having hip or knee replacement for osteoarthritis.

  Recruiting Medical University of Warsaw · Ostrów Mazowiecka, Masovian Voivodeship · NCT07347821

• Frozen versus fresh platelet-rich plasma injections for knee osteoarthritis

  This trial will test whether frozen-stored PRP injections work as well as PRP given at the time of collection to reduce pain and improve function in people aged 40–85 with knee osteoarthritis.

  Recruiting MiKS Hospital · Vitoria-Gasteiz, Araba/Álava · NCT07329361

• Faster rehabilitation after total knee replacement

  This trial will test whether a faster rehabilitation program helps people aged 50–80 recover better and have better quality of life after their first unilateral total knee replacement.

  Recruiting Mahidol University · Dali, Yunnan · NCT07319546

• NTU JO-SMART Program for Obesity and Knee Osteoarthritis

  A program that combines AI-guided community exercise with continuous glucose monitoring to help people who are overweight and have knee OA see if it improves blood sugar and joint health.

  Recruiting at 2 sites National Taiwan University Hospital · Taipei, Taiwan and 1 other locations · NCT07317310

• Return to sports after knee replacement

  This project will try stepwise, sports-style functional tests to see if people with knee replacements can safely return to their sport.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT07183475

• Transarterial microembolization (TAME) for inflamed knee osteoarthritis

  This project will try selective arterial embolization (TAME) to reduce chronic pain in adults with moderate inflammatory knee osteoarthritis who have not improved after at least three months of conservative care.

  Recruiting Istituto Ortopedico Rizzoli · Bologna, Bologna · NCT07140367

• Three-week intensive rehabilitation for people with ongoing problems after total hip or knee replacement.

  This program tests whether three weeks of intensive rehabilitation helps people who continue to have physical problems after total hip or knee replacement.

  Recruiting Horsens Hospital · Brædstrup · NCT07105657

• Evaluating ArtiBest for treating knee osteoarthritis

  This study is testing if a new knee injection called ArtiBest can help people aged 35 to 85 with knee osteoarthritis feel less pain and move better.

  Recruiting Maxigen Biotech Inc. · Kaohsiung City · NCT06994546

• Improving sleep before knee replacement to reduce post-surgical pain

  This study will see if adding cognitive behavioral therapy for insomnia plus morning bright light is better than negative ion exposure with either CBT-I or sleep/knee education at reducing pain after total knee replacement in people 60+ with knee osteoarthritis who have trouble sleeping.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06976138

• Articular noise after two different types of total knee replacement

  This will test whether people who receive one of two types of total knee replacements notice different amounts or kinds of joint noise.

  Recruiting Elsan · Auxerre · NCT06880497

• Comparing robotic and conventional knee replacement methods

  This study is testing whether robotic knee replacement surgery works better than traditional knee surgery for people with severe knee arthritis.

  Recruiting at 2 sites George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures · Cluj-Napoca, Cluj and 1 other locations · NCT06858358

• Testing exercise programs with and without rest for knee osteoarthritis

  This study is testing two different exercise programs for people with knee osteoarthritis to see if taking longer breaks during workouts helps them feel better and move easier.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06857123

• Treatment for knee osteoarthritis using shockwave therapy

  This study is testing if shockwave therapy can help people with knee osteoarthritis after ACL surgery feel less pain and move better compared to those who receive a fake treatment.

  Recruiting Spaulding Rehabilitation Hospital · Cambridge, Massachusetts · NCT06686680

• Total Knee Replacement: post-market safety and effectiveness registry

  This registry tests how well the Freedom Total Knee system works and stays safe after it’s been released, by following a group of patients who have this knee replacement.

  Recruiting at 2 sites Maxx Orthopedics Inc · Leawood, Kansas and 1 other locations · NCT06627699

• Using a smart knee brace with vibration to help treat knee osteoarthritis

  This study is testing a smart knee brace that uses vibrations to see if it can help older adults with knee osteoarthritis move better and feel less pain compared to regular treatments.

  Recruiting National Taiwan University Hospital · Taipei · NCT06616896

Related topics

Quick answers

How many Knee Osteoarthristis clinical trials are recruiting right now?

30, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (8 trials), Taiwan (4 trials), Turkey (Türkiye) (3 trials), Pakistan (3 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →