Dexmedetomidine during hip replacement to modulate nerves and inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial examines two doses of intravenous dexmedetomidine given during spinal anesthesia with a pericapsular nerve group block in adults undergoing total hip arthroplasty for hip osteoarthritis. It is randomized, double-blind, and compares placebo, low-dose, and high-dose dexmedetomidine. The study looks at autonomic regulation, inflammatory biomarkers, postoperative pain, opioid use, and overall recovery quality. All participants receive a standardized surgical and anesthetic plan to isolate the drug’s perioperative effects. Safety considerations include monitoring for known dexmedetomidine-related cardiovascular effects and anesthesia-related risks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 50-90 years.
* Scheduled for elective primary total hip arthroplasty due to primary hip osteoarthritis.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Planned spinal anesthesia combined with ultrasound-guided Pericapsular Nerve Group (PENG) block.
* Ability to understand the study procedures and provide written informed consent.

Exclusion Criteria:

* Refusal to participate or inability to provide written informed consent.
* Contraindications to spinal anesthesia.
* Contraindications to PENG block.
* Allergy or hypersensitivity to dexmedetomidine, ropivacaine, bupivacaine, or study medications.
* Second- or third-degree atrioventricular block without a permanent pacemaker.
* Resting heart rate \<50 beats/min.
* Severe hepatic impairment (Child-Pugh class C).
* Severe renal failure requiring dialysis.
* Chronic opioid therapy (\>3 months before surgery).
* Chronic treatment with α2-adrenergic agonists.
* Cognitive impairment or inability to complete postoperative questionnaires.
* Infection at the injection site.
* Coagulopathy or ongoing anticoagulation precluding neuraxial anesthesia according to current guidelines.
* Revision total hip arthroplasty.
* Simultaneous bilateral total hip arthroplasty.
* Participation in another interventional clinical trial within the previous 30 days.

Where it's running

• Poznan University of Medical Sciences
  Poznan, Poland Recruiting

Study contacts

• Study coordinator: MAlgorzata Reysner, MD PhD
• Email: mreysner@ump.edu.pl
• Phone: +48 61 8310122

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.