Intravenous dexamethasone for better pain control after hip replacement with a PENG block

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized study evaluates intravenous dexamethasone at 0 mg, 4 mg, and 8 mg as an adjunct to standard anesthesia with a PENG block for postoperative analgesia in adults undergoing total hip arthroplasty. The primary outcome is time to first rescue analgesia, with secondary outcomes including pain scores, opioid use, nausea and vomiting, blood glucose, and adverse events. The trial aims to determine if higher IV dexamethasone doses provide meaningful analgesic benefit without increasing risks. Participants are adults with hip OA undergoing elective THA, ASA I–III, and planned regional anesthesia, recruited at Poznan University of Medical Sciences. The study addresses the dose-response relationship of IV dexamethasone in THA with PENG block.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Scheduled for elective total hip arthroplasty (THA)
* Planned use of regional anesthesia including PENG block
* American Society of Anesthesiologists (ASA) physical status I-III
* Ability to understand the study procedures and provide written informed consent
* Ability to assess pain using the Numeric Rating Scale (NRS)

Exclusion Criteria:

* Known hypersensitivity to dexamethasone or any component of the study medication
* Chronic corticosteroid therapy or use of systemic steroids within 14 days prior to surgery
* Active systemic infection or sepsis
* Significant immunosuppression (e.g., chemotherapy, biological therapy)
* Pregnancy or breastfeeding
* Severe cognitive impairment or inability to reliably assess pain
* Uncontrolled diabetes mellitus (e.g., HbA1c \> 8.5% or baseline blood glucose \> 200 mg/dL)

Where it's running

• Poznan University of Medical Sciences
  Poznan, Poland Recruiting

Study contacts

• Principal investigator: Justyna Marszałek-Buko, MD — Poznan University of Medical Sciences
• Study coordinator: Małgorzata Reysner, MD PhD
• Email: mreysner@ump.edu.pl
• Phone: +48 (61) 8310122

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.