PENG nerve block plus dexmedetomidine for hip surgery pain in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, controlled trial in older adults undergoing hip surgery comparing a PENG block with ropivacaine alone versus ropivacaine plus low-dose dexmedetomidine. Participants 65 years and older who are eligible for a PENG block will be randomly assigned to one of the two regimens and followed for postoperative pain scores, opioid consumption, motor function, and complications. The trial is single-center at Poznan University of Medical Sciences and uses ultrasound-guided PENG block as part of multimodal perioperative analgesia. Safety monitoring will include assessment for hemodynamic effects, neurologic status, and adverse events related to regional anesthesia and study drugs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 65 years or older
* Scheduled for elective or emergency hip surgery (e.g., hip fracture fixation or hip arthroplasty)
* ASA physical status I-III
* Ability to communicate pain intensity using the NRS scale
* Written informed consent obtained from the patient or legal representative
* Planned use of PENG block as part of multimodal perioperative analgesia

Exclusion Criteria:

* Patient refusal or inability to provide informed consent
* Allergy, intolerance, or contraindication to any study medication: ropivacaine, dexmedetomidine
* Pre-existing neurological deficit or neuropathy of the affected limb
* Coagulopathy (INR \>1.5, platelets \<100,000/µL) or current therapeutic anticoagulation that contraindicates regional anesthesia
* Infection at or near the injection site
* Severe hepatic or renal impairment
* History of chronic opioid use (daily opioids \>30 days before surgery)
* Cognitive impairment or delirium precluding reliable pain assessment
* BMI \> 40 kg/m² (if you want to exclude for technical difficulty)
* Patients receiving another regional nerve block for hip surgery
* Pregnancy or breastfeeding
* Participation in another interventional clinical trial within 30 days

Where it's running

• Poznan University of Medical Sciences
  Poznan, Poland Recruiting

Study contacts

• Study coordinator: Malgorzata Reysner, MD PhD
• Email: mreysner@ump.edu.pl
• Phone: +48 61 873 83 03

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Spinal anesthesia with intrathecal morphine vs PENG block (with or without dexamethasone) for hip replacement

  In people aged 60 and older undergoing total hip arthroplasty, this study tests whether three anesthesia approaches provide better pain control and fewer side effects: spinal with intrathecal morphine, spinal with a PENG block, or spinal with a PENG block plus dexamethasone.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07584200

• PENG Block or Periarticular Injection for Hip Surgery in Older Adults

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  Recruiting Danderyd Hospital · Danderyd · NCT07839403

• Dexmedetomidine during hip replacement to modulate nerves and inflammation

  A randomized, placebo-controlled study tests whether intravenous dexmedetomidine given during spinal anesthesia with a PENG nerve block can help regulate the body's stress and inflammatory response and improve recovery after hip replacement.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT07743853

• Preoperative Fasting to Shape the Gut with Hip Replacement

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• Mako-MORE Registry: Real-world Outcomes After Knee and Hip Arthroplasty

  This registry collects real-world data from adults having hip or knee joint replacement with or without the Mako robotic system to see how they do over up to five years.

  Recruiting at 2 sites Stryker Orthopaedics · Jacksonville, Florida and 4 other locations · NCT07647354

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.