Condition

Gout clinical trials and research

• 19Clinical trials
• 23NIH research projects
• 12Countries

Newest Gout clinical trials

All recruiting trials (19)

• Dotinurad in gout patients who can’t tolerate XOI or failed uricase treatment

  This trial tests whether dotinurad can lower uric acid levels in adults with gout who can’t use certain standard medicines or have not benefited from uricase.

  Recruiting at 41 sites Phase 2 Crystalys Therapeutics · Birmingham, Alabama and 40 other locations · NCT07535034

• Orienting project on crystal deposits in gout, CPPD, and osteoarthritis

  This project will follow adults with gout or CPPD and people with osteoarthritis to see if crystal deposits in joints and blood vessels change over time and relate to treatments or heart problems.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Milano · NCT07504146

• Remote monitoring for gout in primary care

  This project will test a smartphone self-management app to help adults with gout and high urate levels manage their condition alongside GP follow-up.

  Recruiting Diakonhjemmet Hospital · Oslo · NCT07490522

• Purified Cortrophin® Gel for treating acute gout flares at two dose levels

  This study will try two single injections (40 U and 80 U) of Purified Cortrophin® Gel to see which dose better and more quickly reduces pain in adults having an acute gout flare.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT07346079

• IV PRX-115 at different dose schedules, with or without methotrexate, versus placebo for adults with gout

  This trial will test whether IV PRX-115 given on different schedules, with or without low-dose methotrexate, can lower uric acid and be safe in adults whose gout is not controlled by standard urate-lowering drugs.

  Recruiting at 35 sites Phase 2 Protalix · Glendale, Arizona and 34 other locations · NCT07280156

• Dotinurad versus allopurinol for lowering uric acid in gout

  This trial tests whether dotinurad lowers blood uric acid more than allopurinol in adults with gout.

  Recruiting at 103 sites Phase 3 Crystalys Therapeutics · Birmingham, Alabama and 118 other locations · NCT07089875

• Metformin for safety and benefit in people with gout

  This trial will test whether metformin is safe and helps reduce gout symptoms in people diagnosed with gout.

  Recruiting Phase 2 Tanta University · Tanta · NCT06924658

• Pharmacist-led urate-lowering care to reach target in gout patients

  This study tests whether a pharmacist-led, telehealth approach to ULT management helps veterans with gout reach uric acid goals and reduce flare burden compared with usual care.

  Recruiting at 5 sites VA Office of Research and Development · Omaha, Nebraska and 4 other locations · NCT06887452

• Examining the effects of different exercise levels on arthritis symptoms

  This study tests how different amounts of exercise can help people with arthritis feel better over six months.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT06880653

• Time needed to dissolve gout urate deposits when uric acid is kept very low

  This project tests whether keeping blood uric acid under 40 mg/L in people with gout will dissolve joint urate deposits and how long that takes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06669000

• Evaluating the safety and effects of SSS11 in patients with gout and high uric acid levels

  This study is testing a new treatment called SSS11 to see if it can safely lower uric acid levels in people with gout.

  Recruiting Phase 1 Shenyang Sunshine Pharmaceutical Co., LTD. · Shanghai · NCT06629376

• Lowering or stopping febuxostat in people with gout who have been well controlled for 5+ years

  This test will see if reducing or briefly stopping febuxostat keeps uric acid low and prevents symptom return in people with gout who have had good control for at least five years.

  Recruiting Phase 4 Seoul National University Hospital · Seongnam-si, Gyeonggi-do · NCT06622603

• Improving gout care after emergency department visits

  This study is testing a new way to help people with gout get better follow-up care after visiting the emergency room, especially for those in underserved communities in the Southeastern U.S.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06534554

• Using Peguricase with Methotrexate for Uncontrolled Gout

  This study is testing if combining an injection of peguricase with methotrexate can help people with uncontrolled gout who haven't found relief with standard treatments.

  Recruiting Phase 1 Shanghai Institute Of Biological Products · Bengbu, Anhui · NCT06298071

• Assessing how patient feedback affects treatment adjustments for autoimmune diseases

  This study is testing if regular feedback from patients with autoimmune diseases like gout and rheumatoid arthritis can help doctors make better treatment decisions and improve patient care.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT05927688

• Dapansutrile tablets for treating acute gout flares

  This study is testing if dapansutrile tablets can help people with acute gout flares feel better compared to a placebo.

  Recruiting at 30 sites Phase 2/3 Olatec Therapeutics, Inc. · Birmingham, Alabama and 39 other locations · NCT05658575

• Assessing ultrasound abnormalities in gout patients

  This study is trying to see how common and serious ultrasound findings are in adults with gout to better understand how the condition affects their joints and tendons.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt, APHP · NCT05546593

• Comparing two treatment strategies for managing gout

  This study is testing whether treating gout by aiming for specific blood urate levels works better than just focusing on avoiding symptoms for people with the condition.

  Recruiting at 3 sites Phase 4 Massachusetts General Hospital · South Birmingham, Alabama and 6 other locations · NCT04875702

• Observing crystal-related arthritis conditions

  This study is trying to learn more about conditions like gout and chondrocalcinosis by collecting information from patients and using imaging tests to see how these diseases change over time.

  Recruiting Lille Catholic University · Lomme · NCT04695028

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Treat-to-Target Urate in Gout: A New Approach for Better Pain and Health

  A large clinical trial tests whether aiming for a specific uric acid level in gout patients improves symptoms and health outcomes compared with avoiding symptoms.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11416296

• Translational Genomics in Gout: Linking GWAS Signals to Mechanisms

  Aims to understand why some people with high uric acid develop gout by connecting genetic clues to the biology of joint inflammation.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11412953

• Genetic clues to gout flares through cell gene activity in blood and joint fluid

  Researchers will study how genes turn on or off in immune cells from blood and joint fluid during gout flares to understand why flares happen.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11398134

• Uric acid skin sensor to guide gout treatment and diet

  A skin patch that measures uric acid in sweat is being tested to help people with gout manage their diet and medications better.

  NIH research California Institute of Technology · Pasadena, United States · NIH-11395594

• Wearable skin patch that tracks uric acid and metabolites for people with gout

  A wearable skin patch will measure uric acid and other metabolites around meals to help people with gout make better diet and medication choices.

  NIH research California Institute of Technology · Pasadena, United States · NIH-11383658

• Gout and Kidney Disease: How gout changes as kidney disease gets worse and after kidney transplant

  This project follows people with gout as their kidney disease progresses toward dialysis or transplant, using national kidney data to understand how often gout flares happen and how care needs change.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11370662

• SGLT2 inhibitors for gout care in adults with diabetes

  A randomized trial is testing whether an SGLT2 inhibitor can help reduce gout flares and improve heart and kidney health in adults with type 2 diabetes.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11358299

• How metabolism and chronic inflammation contribute to gout

  This project uses genetic and blood-based measurements from adults to understand why some people with high uric acid develop gout and how metabolic syndrome and long-term inflammation play a role.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11251315

• Investigating the links between metabolic syndrome, chronic inflammation, and gout

  This study is looking at how gout, a painful type of arthritis, is related to metabolic syndrome, which includes issues like insulin resistance, to help patients understand their condition better and find new ways to treat it.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11239944

• What triggers gout flares: looking at immune cells in joints and blood

  Researchers will compare immune cell activity in joint fluid and blood from people with gout before and during flares to find genes that drive attacks.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11194466

• How genetic differences and DNA changes lead to gout

  This project looks at how inherited genes and DNA-based cell changes make adults with high uric acid more likely to have gout flares.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11191544

• Pharmacist-led Targeted Urate Lowering Therapy for Gout in Veterans

  A pharmacist-led program will use a target-uric-acid approach to improve gout control in Veterans receiving care at VA centers.

  NIH research Omaha VA Medical Center · Omaha, United States · NIH-11182124

• Targeting low blood uric acid versus treating gout flares for adults with gout

  This compares keeping blood uric acid below a set level versus treating gout flares only, for adults living with gout.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11171432

• Understanding Gout and High Uric Acid Through Body Chemistry and Gut Bacteria

  This project aims to understand how body chemistry and gut bacteria contribute to high uric acid and gout, a painful form of arthritis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11064865

• Using SGLT2 inhibitors to improve gout care

  This study is looking at whether a type of medication called SGLT2 inhibitors can help people with gout feel better and reduce their risk of heart problems, and it’s for adults who experience gout flare-ups.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11047879

• Improving gout treatment with engineered uricase

  This study is working on a new version of an enzyme that helps lower uric acid levels, aiming to create a safer and more effective treatment for people with gout who haven't found relief with other options.

  NIH research Cyrus Biotechnology, INC. · Seattle, United States · NIH-11008432

• Understanding the causes of gout flares through blood and joint cell analysis.

  This study is looking at how your genes and immune system work during gout flares by collecting blood and joint fluid samples from people like you, to help find out what triggers the pain and swelling.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10995564

• Understanding the genetics of gout and its inflammatory mechanisms

  This study is looking at how our genes might play a role in causing gout, a type of arthritis that causes painful swelling in the joints, and it invites people with high uric acid levels to share their genetic samples and health info to help researchers understand this better.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10933448

• Comparing treatment strategies for managing gout symptoms and serum urate levels

  This study is looking at two ways to help people with gout: one that tries to lower uric acid levels in the blood and another that focuses on easing pain and other symptoms, so if you have gout, you can help us find out which method works better for your health!

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10917026

• Investigating the causes of recurrent gout flares

  This study is looking at how specific immune cells in people with gout react to crystals that cause flare-ups, hoping to find clues that could help manage these painful attacks better for those who have them often.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10906714

• Personalized care for gout and related health issues

  This study is looking to make gout treatment better by creating personalized care plans that take into account your other health issues, so you can feel your best while managing your gout.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10867510

• Investigating the causes of recurrent gout flares

  This study is looking at how specific immune cells in people with gout react to crystals that cause flare-ups, hoping to find out why some patients have more frequent attacks than others, which could help improve treatment options for everyone with gout.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10693097

• Monitoring uric acid levels in sweat to improve gout treatment

  This study is testing a new skin patch that can check your uric acid levels through your sweat, helping you see how your diet affects your gout in real-time, and it’s looking for people to join a 10-week trial to see how well it works.

  NIH research California Institute of Technology · Pasadena, United States · NIH-10642949

Related topics

Quick answers

How many Gout clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (9 trials), France (5 trials), Israel (2 trials), Spain (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 3, Phase 1: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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