Understanding the genetics of gout and its inflammatory mechanisms
Translational genomics in gout: From GWAS signal to mechanism
This study is looking at how our genes might play a role in causing gout, a type of arthritis that causes painful swelling in the joints, and it invites people with high uric acid levels to share their genetic samples and health info to help researchers understand this better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10933448 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to gout, a common form of arthritis characterized by sudden and severe pain due to inflammation in the joints. By analyzing data from a large genome-wide association study, the team aims to identify specific genetic loci associated with gout and understand how these genetic variations influence the body's inflammatory response. The study focuses on the role of certain long-noncoding RNAs and their impact on gene expression and immune responses, particularly in individuals with high levels of uric acid. Patients may be involved in providing genetic samples and health information to help uncover these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults with a history of gout or hyperuricemia, particularly those who are African American or from the Birmingham area.
Not a fit: Patients without a diagnosis of gout or those who do not have elevated uric acid levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for gout, potentially reducing the frequency and severity of flare-ups.
How similar studies have performed: Previous research has successfully identified genetic factors related to gout, suggesting that this approach has the potential for meaningful insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Merriman, Tony R — University of Alabama at Birmingham
- Study coordinator: Merriman, Tony R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.