Investigating the causes of recurrent gout flares
Functional and Integrative Omics of Recurrent Gout Flares
This study is looking at how specific immune cells in people with gout react to crystals that cause flare-ups, hoping to find out why some patients have more frequent attacks than others, which could help improve treatment options for everyone with gout.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10693097 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain immune cells, specifically neutrophils and monocytes, respond to monosodium urate crystals that trigger gout attacks. By analyzing blood samples from gout patients, the study aims to identify differences in gene expression and DNA methylation between those who experience recurrent flares and those who do not. The research utilizes advanced techniques like RNA sequencing to uncover molecular factors that may contribute to these flares, potentially leading to improved patient care and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gout, particularly those experiencing recurrent flares.
Not a fit: Patients who do not have gout or those who have not experienced recurrent flares may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management and prevention of recurrent gout flares for patients.
How similar studies have performed: Other research has shown promise in understanding inflammatory responses in gout, but this specific approach focusing on gene expression and DNA methylation is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Reynolds, Richard James — University of Alabama at Birmingham
- Study coordinator: Reynolds, Richard James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.