Gout and Kidney Disease: How gout changes as kidney disease gets worse and after kidney transplant
Official title: Gout Epidemiology in Chronic Kidney Disease: Transition to End-stage Kidney Disease and Impact of Renal Transplant
Funded at University of Alabama at Birmingham · NIH-11370662 · Data updated 2026-11-12
This project follows people with gout as their kidney disease progresses toward dialysis or transplant, using national kidney data to understand how often gout flares happen and how care needs change.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 10, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $186,134 |
| NIH project number | 5R01AR085886-02 |
| Project ID | NIH-11370662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with gout and chronic kidney disease transitioning toward dialysis or kidney transplantation.
✕Less likely to help
People without gout or CKD, or those not undergoing dialysis or transplantation, may not directly benefit.
What this research studies
Gout and advanced kidney disease often occur together, but we don’t know enough about how gout behaves during the transition to dialysis or kidney transplant. The study will use large US databases to track gout flares, ER visits, hospitalizations, and cardiovascular events as CKD worsens and patients move toward ESKD and transplantation. Researchers will apply a statistical approach that lets each person serve as their own comparison over time, helping to clarify how gout burden shifts across stages of kidney disease and after transplantation. The findings could guide better gout management and reduce complications for people with CKD as they consider dialysis or KT.
Why it matters
Potential benefit: If successful, the research could inform tailored gout management during kidney disease progression and after transplant, potentially reducing flares and healthcare use.
How similar studies have gone: Previous work has shown changing medication effects with kidney function, but this study is among the first to examine gout burden across the full dialysis/KT transition using self-controlled methods.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Gaffo, Angelo L — University of Alabama at Birmingham
- Study coordinator: Gaffo, Angelo L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.