Condition

Joint Pain clinical trials and research

• 10Clinical trials
• 7NIH research projects
• 8Countries

Newest Joint Pain clinical trials

All recruiting trials (10)

• Hydroxychloroquine for AIMSS in breast cancer patients on aromatase inhibitors

  This study tests whether hydroxychloroquine can reduce joint pain in people with breast cancer who are taking aromatase inhibitors and have AIMSS.

  Recruiting Phase 2 Indiana University · Indianapolis, Indiana · NCT07825454

• Collagen and omega-3 supplements in middle-aged women

  This study tests whether taking collagen and omega-3s together improves joint pain, fatigue, sleep, and overall wellbeing in healthy women aged 35–65 compared with a placebo over 8 weeks.

  Recruiting Loughborough University · Loughborough · NCT07740967

• Creatine or placebo to test effects on cognition, muscle strength, and body composition in middle-aged women

  This study tests whether taking creatine daily for 8 weeks improves thinking, strength, fatigue, and body composition in healthy middle-aged women compared to a placebo.

  Recruiting Loughborough University · Loughborough · NCT07729930

• JDS-HF3.0 supplement to ease menopause symptoms in postmenopausal women

  This trial will see if taking two JDS-HF3.0 tablets each morning for 12 weeks can reduce hot flashes, night sweats, and joint discomfort in postmenopausal women aged 50–70.

  Recruiting Bonafide Health · Harrison, New York · NCT07238478

• Auricular point acupressure self-management for chronic musculoskeletal pain in rural communities

  This program will test whether a 4-week auricular point acupressure self-management approach (delivered via a smartphone app with remote training or with in-person training) helps adults in rural areas reduce chronic musculoskeletal pain and improve activity.

  Recruiting The University of Texas Health Science Center, Houston · Columbia, South Carolina and 2 other locations · NCT07179016

• Wild blueberry powder for joint and gut health

  This trial will test whether taking 25 g of freeze-dried wild blueberry powder daily for 12 weeks changes gut bacteria, lowers inflammation markers, and improves joint pain in adults with multi-joint or knee arthritis.

  Recruiting University of Nevada, Las Vegas · Oklahoma City, Oklahoma · NCT06828159

• Evaluating treatments for joint pain in menopausal women

  This study is testing whether muscle strengthening exercises, estrogen therapy, or a combination of both can help relieve joint pain in women going through menopause.

  Recruiting Phase 2/3 National University Hospital, Singapore · Singapore · NCT06530459

• Tart cherry and fish oil for aromatase inhibitor–related joint pain

  This project will test whether taking tart cherry concentrate plus fish oil for 12 weeks reduces joint pain and stiffness in women with breast cancer who are taking aromatase inhibitors.

  Recruiting Early Phase 1 Cedars-Sinai Medical Center · Los Angeles, California and 1 other locations · NCT06123286

• Comparing two types of nerve blocks for knee surgery

  This study is testing which type of nerve block works better for pain control and recovery in people having knee surgery.

  Recruiting Luzerner Kantonsspital · Lucerne · NCT06074744

• Dapansutrile tablets for treating acute gout flares

  This study is testing if dapansutrile tablets can help people with acute gout flares feel better compared to a placebo.

  Recruiting at 30 sites Phase 2/3 Olatec Therapeutics, Inc. · Birmingham, Alabama and 39 other locations · NCT05658575

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mechano-triggered non-opioid pain relief for post-surgery joint pain

  A first-in-kind delivery system uses body movements to release pain-relieving drugs after joint surgery, aiming to reduce opioid use.

  NIH research Mechano Therapeutics LLC · Philadelphia, United States · NIH-11409518

• Understanding TMJ Pain: How Jaw Joint and Muscle Signals Cause Chronic Pain

  A study at a major university aims to uncover how nerves in the jaw area create lasting pain in adults with jaw and muscle discomfort.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11376276

• Short-chain fatty acids in chronic jaw (TMJ) pain

  This work looks at whether restoring gut short-chain fatty acids can help ease long-term jaw (TMJ) pain by changing how pain-related genes are controlled.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11258910

• Understanding the causes of ongoing joint pain in people with psoriatic arthritis

  This study is looking at what causes ongoing joint pain in people with psoriatic arthritis, using special imaging techniques to better understand both the physical and emotional aspects of pain, with the goal of finding better ways to help manage it.

  NIH research New York University School of Medicine · New York, United States · NIH-11058509

• Investigating the role of gut bacteria and short-chain fatty acids in chronic jaw pain

  This study is looking at how changes in gut bacteria and certain substances called short-chain fatty acids might be linked to chronic pain in the jaw joint, and it could lead to a new treatment option for people suffering from TMJ pain.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-10994638

• Exploring a new method to relieve facet joint pain using electrical stimulation

  This study is looking at how a gentle electrical stimulation method called peripheral nerve stimulation (PNS) can help relieve facet joint pain from chronic back problems, offering a safer option that protects your muscles while aiming to ease your discomfort.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-10734693

• Understanding joint pain and developing personalized treatments

  This study is exploring how joint pain works in people with osteoarthritis by using a special model that acts like a real joint, with the goal of finding better ways to manage pain for those who suffer from this condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10387104

Related topics

Quick answers

How many Joint Pain clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (6 trials), United Kingdom (2 trials), France (1 trial), Israel (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 2, Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →