SGLT2 inhibitors for gout care in adults with diabetes
Official title: SGLT2i As Novel Gout Care (SAVE-Care): A Randomized Controlled Trial
Funded at Massachusetts General Hospital · NIH-11358299 · Data updated 2026-11-12
A randomized trial is testing whether an SGLT2 inhibitor can help reduce gout flares and improve heart and kidney health in adults with type 2 diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 18, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $219,637 |
| NIH project number | 5R61AR084188-02 |
| Project ID | NIH-11358299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) with adult-onset diabetes mellitus and gout who meet the study's inclusion criteria.
✕Less likely to help
Some participants may not experience a noticeable reduction in gout flares or cardiometabolic benefits.
What this research studies
This study targets adults with type 2 diabetes who also have gout, aiming to see if an SGLT2 inhibitor can lessen gout flares while also benefiting heart and kidney outcomes. Participants will be randomized to receive the SGLT2 inhibitor or standard care, with careful monitoring of gout activity, uric acid levels, and cardiovascular and kidney markers. The approach builds on prior evidence that SGLT2 inhibitors offer heart and kidney benefits and may lower uric acid, potentially addressing both gout symptoms and cardiometabolic risk.
Why it matters
Potential benefit: If successful, this could reduce gout flares and lower cardiovascular and kidney risks for people with diabetes and gout.
How similar studies have gone: Previous studies in diabetes have shown cardiovascular and kidney benefits with SGLT2 inhibitors, though their impact on gout specifically is being explored here.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Choi, Hyon K — Massachusetts General Hospital
- Study coordinator: Choi, Hyon K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.