Understanding the causes of gout flares through blood and joint cell analysis.
Revealing novel mechanisms of gout flares by transcriptional phenotyping synovial and peripheral blood mononuclear cells.
This study is looking at how your genes and immune system work during gout flares by collecting blood and joint fluid samples from people like you, to help find out what triggers the pain and swelling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10995564 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms behind gout flares by analyzing blood and joint fluid samples from patients. It focuses on comparing gene expression in immune cells during active gout flares to identify potential triggers and pathways involved in inflammation. Participants will be involved in a clinical trial that requires consent for sample collection during flare episodes, allowing researchers to gather critical data on how gout affects the body at a cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gout who experience recurrent flares.
Not a fit: Patients who do not have a diagnosis of gout or those who do not experience gout flares may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of gout flares, potentially improving treatment options for patients.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding inflammatory conditions through gene expression analysis.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Merriman, Tony R — University of Alabama at Birmingham
- Study coordinator: Merriman, Tony R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.