Comparing treatment strategies for managing gout symptoms and serum urate levels
Treat-to-Target Serum Urate versus Treat-to-Avoid Symptoms in Gout: A Randomized Controlled Trial (TRUST)
This study is looking at two ways to help people with gout: one that tries to lower uric acid levels in the blood and another that focuses on easing pain and other symptoms, so if you have gout, you can help us find out which method works better for your health!
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10917026 on NIH RePORTER |
What this research studies
This research investigates two different approaches to treating gout: one that aims to lower serum urate levels to a specific target and another that focuses on alleviating symptoms. By conducting a randomized controlled trial, the study will involve collaboration between rheumatologists and primary care providers to gather high-level evidence on the effectiveness of these strategies. Patients will be monitored for changes in their gout symptoms and overall health outcomes, including potential impacts on kidney function and cardiovascular health. The goal is to provide clearer guidelines for gout management based on solid evidence.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with gout.
Not a fit: Patients who do not have gout or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for gout, improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown that targeting serum urate levels can be beneficial in managing gout, but this specific comparative approach is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Choi, Hyon K — Massachusetts General Hospital
- Study coordinator: Choi, Hyon K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.