Using SGLT2 inhibitors to improve gout care
SGLT2i As Novel Gout Care (SAVE-Care): A Randomized Controlled Trial
This study is looking at whether a type of medication called SGLT2 inhibitors can help people with gout feel better and reduce their risk of heart problems, and it’s for adults who experience gout flare-ups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11047879 on NIH RePORTER |
What this research studies
This research investigates the potential of sodium-glucose cotransporter-2 inhibitors (SGLT2i) to improve the management of gout, a common inflammatory arthritis affecting millions of adults. The study aims to evaluate how these medications can reduce gout flares and associated cardiovascular risks, which are significant concerns for patients with this condition. By conducting a randomized controlled trial, the research will compare the effects of SGLT2i on gout symptoms and overall health outcomes against standard treatments. Patients participating in this trial will be closely monitored to assess the effectiveness of this novel approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with gout and may also have cardiovascular or kidney comorbidities.
Not a fit: Patients who do not have gout or those with contraindications to SGLT2 inhibitors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for gout patients, reducing flare-ups and associated cardiovascular risks.
How similar studies have performed: Previous studies have shown that SGLT2 inhibitors can provide cardiovascular and kidney benefits, suggesting a promising avenue for gout management.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Choi, Hyon K — Massachusetts General Hospital
- Study coordinator: Choi, Hyon K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.