Condition
Rheumatoid Arthritis (RA) clinical trials and research
As of November 12, 2026, Find a Trial lists 73 Rheumatoid Arthritis (RA) clinical trials that are recruiting, at sites in 31 countries (most in China (15), United States (12), Egypt (7)). 1 was first registered in the last 30 days. By phase: Phase 1 (13), Phase 2 (10), Phase 4 (9), Early Phase 1 (3). The most active sponsors are Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (3), Kali Therapeutics, Inc. (2), Peking University People's Hospital (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 73Clinical trials
- 1New in 30 days
- 31Countries
Newest Rheumatoid Arthritis (RA) clinical trials
All recruiting trials (73)
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Heart Rate Variability and Rheumatoid Arthritis: What HRV Looks Like with RA
This study checks whether continuous HRV data from an Oura ring can reflect RA disease activity in adults with RA.
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Discontinuing MTX or LEF in RA Patients on TNF Inhibitors
This trial tests whether stopping methotrexate or leflunomide while continuing a TNF inhibitor is not worse for disease control in adults with rheumatoid arthritis.
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FT839 therapy for autoimmune diseases
This trial tests FT839, given alone or with rituximab, to see if it is safe and can help people with certain autoimmune diseases who have not responded to other treatments.
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24-Hour Movement and Atherosclerotic Risk in adults with rheumatoid arthritis
This study tests how daily activity, sitting, and sleep relate to heart-related risk in adults with RA, using wearables and follow-up after a year.
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Integrative AI profiling of chronic RA pain
This study tests whether an AI-driven multiomic and neurophysiological approach can help explain and predict persistent pain in adults with active rheumatoid arthritis.
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Oxidative Stress and Heart Risk in People with Rheumatoid Arthritis
This study tests whether certain markers of oxidative stress in people with rheumatoid arthritis are linked to subclinical atherosclerosis and arterial stiffness, which could relate to future heart disease risk.
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Diosmin or Rebamipide as Add‑ons to Standard RA Therapy
This study tests whether adding diosmin or rebamipide to standard rheumatoid arthritis therapy helps patients achieve better control of their disease compared with standard therapy alone.
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Nicorandil for rheumatoid arthritis: a two-phase study comparing it to placebo
This trial tests whether nicorandil twice daily for 3 months can reduce rheumatoid arthritis symptoms compared with a placebo.
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Integrated traditional and Western medicine approach for refractory rheumatoid arthritis
This trial tests whether Kunxian Capsule, added to standard rheumatoid arthritis therapies, helps people with difficult-to-treat RA see better results.
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JAB-8263 in active rheumatoid arthritis
A Phase 2a open-label study tests JAB-8263 in adults with active rheumatoid arthritis to see if it is safe and can have preliminary signs of benefit.
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Predicting safe tapering of biologic therapy for rheumatoid arthritis in remission
This study tests whether a predictive tool called OPTIBIO can help doctors decide when it’s safe to reduce biologic therapy in RA patients who are in remission.
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Evening vs morning JAK inhibitor for rheumatoid arthritis
This observational study tests whether taking a JAK inhibitor in the evening works better than in the morning for adults with rheumatoid arthritis.
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BloodTrackR Usability and Concordance in RA
This study tests a home blood collection device and accompanying app for people with rheumatoid arthritis to see if they can collect usable samples at home and whether the results match standard blood tests.
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Gluten-Free vs Mediterranean Diet in Rheumatoid Arthritis
This study tests whether gluten-free or Mediterranean diets can affect disease activity and quality of life in people with rheumatoid arthritis over 12 weeks.
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Desloratadine as Add-On Therapy for Rheumatoid Arthritis
This study tests whether adding desloratadine to standard RA treatment can help reduce disease activity in adults with active rheumatoid arthritis.
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Add-on Roflumilast for active rheumatoid arthritis
This study tests whether adding roflumilast to standard RA treatment helps reduce disease activity in adults with active rheumatoid arthritis.
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Complementary Chinese Herbal Approach to RA Management
This trial tests a modified Si Miao Xiao Bi Tang (Chinese herbal medicine) added to methotrexate to see if it helps people with active rheumatoid arthritis.
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Effect of smartphone use on neck posture and function in RA/AS patients and healthy controls
This study tests how smartphone use relates to neck posture, tongue pressure, balance, and neck-related disability in people with rheumatoid arthritis or ankylosing spondylitis compared with healthy individuals.
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Carotid ultrasound to guide prevention of heart disease in inflammatory rheumatic diseases
In people with inflammatory rheumatic diseases like RA, PsA, AxSpA, or SLE who are at modest cardiovascular risk, a carotid ultrasound test is used to see if they should start stronger lipid-lowering therapy to prevent heart problems.
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KT502 first-in-human test in adults with rheumatoid arthritis
A first-in-human, Phase 1 study will test KT502 in adults with moderately to severely active rheumatoid arthritis to see if it is safe and tolerable.
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Oxidative stress in autoimmune joint diseases
Researchers will see if oxidative stress and antioxidant markers differ in adults with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis.
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Ketogenic versus Carnivore (Lion) diets for inflammatory bowel disease and rheumatoid arthritis
This trial will test whether a ketogenic diet or a carnivore (lion) diet can reduce symptoms, improve quality of life, and lower inflammation in adults with IBD or rheumatoid arthritis.
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Integrated Traditional Chinese and Western treatment for rheumatoid arthritis
This project will try combining Traditional Chinese Medicine with Western treatments in people with rheumatoid arthritis, including those with difficult-to-treat disease and lung involvement.
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Using long-lived immune cells to calm an overactive immune system
This trial will try QEL-005, an autologous CD19-directed CAR-T regulatory cell therapy, to calm immune overactivity in adults with diffuse cutaneous systemic sclerosis or difficult-to-treat rheumatoid arthritis.
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Subcutaneous methotrexate for Chinese adults with rheumatoid arthritis
This project will test how well and how safely subcutaneous methotrexate works for Chinese adults with rheumatoid arthritis, including people with lung or coronary comorbidities.
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Lavender aromatherapy massage for wrist pain and movement in rheumatoid arthritis
This study tests whether lavender aromatherapy massage added to usual care can reduce wrist pain and improve mobility in people with rheumatoid arthritis.
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S-4321 in adults with autoimmune or immune-mediated diseases
This study tests S-4321 in adults with autoimmune conditions to see if it is safe and tolerable and to gather early data on how the drug behaves in the body and its initial effects on disease markers.
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Mediterranean versus Paleolithic diet for adults with rheumatoid arthritis
This 12-week trial will see if following a Mediterranean or Paleolithic eating plan helps adults aged 40–60 with rheumatoid arthritis compared with continuing their usual diet.
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HbA1c accuracy in people with inflammatory arthritis on sulfasalazine
This study tests whether HbA1c reliably reflects blood glucose in adults with inflammatory arthritis who are treated with sulfasalazine, by comparing it to continuous glucose monitoring.
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TollB-001 oral tablets for moderate to severe rheumatoid arthritis
This trial tests whether taking daily TollB-001 tablets for four weeks is safe and helps adults (18–70) with moderate to severe rheumatoid arthritis who did not respond to at least one conventional DMARD.
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Long-term follow-up after KYV-101 (CAR T) treatment
This follow-up will test how long KYV-101 CAR T cells persist and record any delayed side effects in people who previously received KYV-101 for autoimmune diseases like lupus nephritis, myasthenia gravis, stiff person syndrome, rheumatoid arthritis, or multiple sclerosis.
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Swallowing problems in rheumatoid arthritis
This study will test whether a flexible fiberoptic throat exam can find joint-related swallowing problems and what predicts swallowing severity in adults with rheumatoid arthritis.
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A-319 for active rheumatoid arthritis
This trial will test whether A-319 is safe and tolerable and may help people with active rheumatoid arthritis who have not responded to multiple prior therapies.
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Coronary calcium and high-sensitivity troponin testing in people with rheumatoid arthritis
This study will test whether measuring coronary artery calcium and high-sensitivity troponin can find people with rheumatoid arthritis who should start cholesterol-lowering treatment even if general risk calculators don't recommend it.
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Pain neuroscience education and vagal nerve stimulation to help people with rheumatoid arthritis
This study tests whether pain neuroscience education, vagal nerve stimulation, or a standard exercise program can improve pain, function, and quality of life for adults with rheumatoid arthritis.
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100% plant-based diet for adults with rheumatoid arthritis
This trial will test whether following a 100% plant-based diet for 16 weeks helps adults with rheumatoid arthritis lower disease activity, reduce symptoms, and improve quality of life.
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LY4213663 in healthy people and people with rheumatoid arthritis
This will test whether LY4213663 is safe and how the body handles it in healthy volunteers and people with rheumatoid arthritis.
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F8IL10 injections directly into a swollen joint for rheumatoid arthritis
This trial tests whether injecting F8IL10 into a single swollen joint is safe and what dose adults with rheumatoid arthritis can tolerate.
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Comparing a one-time intramuscular steroid shot versus a short oral steroid course for RA flares
This tests whether a single intramuscular steroid injection or a short course of oral steroid pills gives better symptom relief for people with rheumatoid arthritis who are experiencing a flare.
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First-in-human KT501 for rheumatoid arthritis
This Phase 1, open-label test will give a single under-the-skin dose of KT501 to adults with moderate to severe rheumatoid arthritis to see if it is safe and how it acts in the body.
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Peer health coaching to reduce anxiety and depression in people with rheumatoid arthritis
This program will test whether peer health coaching helps adults with rheumatoid arthritis reduce symptoms of anxiety or depression over six months.
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CIGB-814 safety and how the body handles it in healthy Chinese adults
We will test whether CIGB-814 is safe, well-tolerated, and how the body processes it in healthy Chinese adults aged 18–45.
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Lowering JAK inhibitor doses in people with RA, PsA, or axSpA who are in low disease activity or remission
This study will test whether carefully lowering the dose of Janus kinase inhibitors keeps disease control as well as staying on the same dose in people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are in remission or have low disease activity.
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Personalized lab test to predict the best treatment for rheumatic diseases
This project tests a lab-based cell assay to see if it can predict which DMARD will work best for adults with autoimmune rheumatic diseases such as RA, PsA, axSpA, and GCA.
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99mTc-CTR-FAPI SPECT imaging to detect inflamed joints in rheumatoid arthritis
This trial will test whether 99mTc-CTR-FAPI SPECT scans can detect active joint inflammation as well as 68Ga-FAPI PET/CT in adults with moderate-to-high rheumatoid arthritis.
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Long-term safety follow-up after gene-modified regulatory T cell (Treg) therapy
This study will see if any delayed side effects occur over 15 years in people who previously got a Sonoma Biotherapeutics gene-modified Treg treatment for conditions like rheumatoid arthritis or hidradenitis suppurativa.
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Testing ADI-001 in people with treatment-refractory rheumatoid arthritis
This Phase 1 test will try ADI-001 with two different pre-treatment (lymphodepletion) regimens in adults whose rheumatoid arthritis has not improved with standard therapies.
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Butantan live tetravalent dengue vaccine for people with autoimmune rheumatic diseases
This study will test whether a single dose of the Butantan live tetravalent dengue vaccine is safe and produces immune responses in clinically stable people aged 12–59 with autoimmune rheumatic diseases compared with matched healthy volunteers.
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HBI0101 CAR-T for refractory B‑cell autoimmune rheumatic diseases
This will test a single infusion of HBI0101 CAR‑T cells in adults with severe, treatment‑resistant B‑cell autoimmune diseases such as SLE, systemic sclerosis, idiopathic inflammatory myopathy, rheumatoid arthritis, or primary progressive MS.
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Training primary care providers to manage rheumatoid arthritis versus rheumatologist care
This trial will test whether primary care doctors who completed a focused RA training program can safely manage stable adults with rheumatoid arthritis as well as their rheumatologist over one year.
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AI-guided precision immunotherapy for rheumatoid arthritis
This trial will see if adding the dnaJP1 peptide to hydroxychloroquine helps adults with moderately to severely active rheumatoid arthritis who have not used DMARDs or biologic treatments.
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UTAA91 injection for refractory rheumatoid arthritis
This trial will test whether injecting UTAA91 is safe for adults with moderate-to-severe rheumatoid arthritis that has not responded to standard treatments.
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Subcutaneous CLN-978 for treatment‑refractory rheumatoid arthritis
This Phase I trial tests a subcutaneously given drug called CLN-978 that redirects T cells to CD19 to try to help people with treatment‑refractory, B‑cell–driven rheumatoid arthritis.
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AlloNK® therapy combined with rituximab for treating certain autoimmune diseases
This study is testing if a new treatment called AlloNK® combined with rituximab can help people with tough-to-treat autoimmune diseases feel better.
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YTS109 cell therapy for relapsed or refractory systemic autoimmune diseases
This trial will try a single infusion of YTS109 cells to see if it's safe and helps adults 18–65 with relapsed or refractory systemic autoimmune diseases such as SLE, systemic sclerosis, inflammatory myopathies, ANCA-associated vasculitis, or antiphospholipid syndrome.
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Single hiSC injection into the knee for rheumatoid arthritis
This study will try a single injection of lab-made human Sertoli cells (hiSCs) into an inflamed knee to see if it helps adults with rheumatoid arthritis who still have knee swelling and pain despite standard treatment.
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Testing QLS12010 Capsules in Healthy Adults
This study is testing if QLS12010 Capsules are safe and how well they are tolerated by healthy adults while also looking at how food affects the way the body absorbs the drug.
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Cizutamig for refractory seropositive rheumatoid arthritis
This trial tests whether cizutamig, a BCMAxCD3 T‑cell engager, is safe and can help adults with seropositive rheumatoid arthritis that has not responded to other treatments.
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Predicting response to low-dose rituximab for rheumatoid arthritis
We will test whether a blood-based pharmacological model can predict which adults with rheumatoid arthritis will respond to a lower rituximab dose (1000 mg once per cycle).
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Measuring Methotrexate Levels in Rheumatoid Arthritis Patients
This study is testing how methotrexate levels change in people with rheumatoid arthritis when they switch from taking it by mouth to getting it as an injection, and how these levels relate to the treatment's effectiveness and safety.
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200 mg rituximab every six months for maintenance in rheumatoid arthritis
This will test whether giving 200 mg of rituximab every six months keeps rheumatoid arthritis under control in people already on rituximab who have low disease activity.
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Safety evaluation of CC312 in patients with autoimmune diseases
This study is testing a new treatment called CC312 to see if it's safe and tolerable for adults with autoimmune diseases like lupus and rheumatoid arthritis.
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Examining the effects of different exercise levels on arthritis symptoms
This study tests how different amounts of exercise can help people with arthritis feel better over six months.
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At-risk rheumatoid arthritis cohort to see if exposures predict early arthritis
This study follows people at high risk for rheumatoid arthritis to see if factors like smoking, diet, or stress can predict the development of arthritis over two years.
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Assessing exercise capacity in rheumatoid arthritis patients using a 6-minute step test
This study is testing if a simple 6-minute step test can help people with rheumatoid arthritis measure their exercise ability better than the usual bike test.
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Auricular (ear) vagus nerve stimulation for rheumatoid arthritis
This trial will test a non-invasive ear-based electrical stimulator (taVNS) to see if it lowers inflammation and improves symptoms in adults with moderate-to-severe rheumatoid arthritis who haven't responded to biologic or targeted DMARDs.
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L-carnitine supplementation for rheumatoid arthritis patients
This study is testing if adding L-carnitine to the usual treatments can help adults with rheumatoid arthritis feel better and improve their joint health.
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Investigating the Role of Y Chromosome Mutations in Autoimmune Diseases
This study is trying to see how changes in the Y chromosome might affect the immune system and contribute to autoimmune diseases like Giant Cell Arteritis and Polymyalgia Rheumatica.
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Using a wearable device to manage work-related shoulder pain
This study is testing a wearable device that helps workers with shoulder pain by giving them feedback on their movements to see if it can make their pain and work limitations better.
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JAK inhibitor tapering strategy in rheumatoid arthritis patients with low disease activity
This study tests if lowering the dose of a JAK inhibitor is feasible for adults with rheumatoid arthritis who are in low disease activity, by comparing tapering versus staying on full-dose therapy.
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Evaluating the effects of oral AP1189 in early rheumatoid arthritis patients
This study is testing if a new oral medication called AP1189 can help people with early rheumatoid arthritis feel better when taken with methotrexate.
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Evaluating DR-0201 for autoimmune diseases
This study is testing a new drug called DR-0201 to see if it can help people with autoimmune diseases like lupus and Sjogren's syndrome feel better and how safe it is.
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Evaluating COVID-19 and influenza vaccine schedules for immunocompromised individuals
This study is testing different ways to give COVID-19 and flu vaccines to people with weakened immune systems to see which method works best for their protection.
Related topics
Quick answers
How many Rheumatoid Arthritis (RA) clinical trials are recruiting right now?
73, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 31 countries. The most sites are in China (15 trials), United States (12 trials), Egypt (7 trials), Germany (6 trials), France (5 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 13, Phase 2: 10, Phase 4: 9, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.