Can CZT-SPECT/CT quantify myocardial tracer uptake to match PET measurements in coronary artery disease?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This exploratory study evaluates if newer CZT-SPECT/CT cameras can provide absolute quantification of myocardial tracer uptake, using standardized uptake values, during rest and stress. Primary goal is to compare stress-to-rest SUV ratios from SPECT with myocardial flow reserve from PET imaging. Participants are adults with suspected or known coronary disease referred for functional cardiac imaging after prior angiography showing non-obstructive to moderate disease. The study uses stress and rest SPECT/CT imaging to assess feasibility of substituting or supplementing PET-based quantification. The investigation is conducted at a single center in Orléans, with eligibility criteria focusing on those without severe disease or prior revascularization and adequate imaging compatibility.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Participant has provided informed consent to participate in the study.
2. Age ≥ 18 years.
3. Patients referred for functional cardiac imaging assessment (SPECT or PET) following diagnostic coronary CT angiography (CCTA) or invasive coronary angiography demonstrating either:

   * moderate coronary atherosclerosis without significant coronary stenosis (\<50% stenosis), or
   * coronary lesions for which functional cardiac imaging assessment or medical therapy is indicated.

Exclusion Criteria:

1. Severe coronary artery disease requiring prompt revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), including left main coronary artery stenosis \>50% or other severe coronary lesions with FFR \<0.80.
2. History of coronary revascularization (PCI, coronary stenting, or CABG).
3. Left ventricular ejection fraction (LVEF) \<35%.
4. Contraindication to pharmacological stress testing for cardiac PET/SPECT, including severe hypotension, second- or third-degree atrioventricular block, or recent myocardial infarction.
5. Protected adult under legal guardianship or curatorship.
6. Individual under judicial protection measures.
7. Individual deprived of liberty.
8. Individual not affiliated with a health insurance
9. Pregnant or breastfeeding woman.

Where it's running

• Centre Hospitalier Universitaire d'Orléans
  Orléans, Loiret, France Recruiting

Study contacts

• Principal investigator: Matthieu BAILLY, Professor — Centre Hospitalier Régional d'Orléans
• Study coordinator: Matthieu BAILLY, Professor
• Email: matthieu.bailly@chu-orleans.fr
• Phone: 0238575078

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.