Ultrasound vs CT calcium scoring to reclassify symptomatic chest pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In people with chest pain and suspected chronic coronary syndrome, current first-line testing often uses CT coronary calcium scoring to rule out obstructive disease, but this imaging involves radiation. The study investigates whether a carotid ultrasound, a radiation-free and quicker test, provides similar reclassification of risk when compared with CT calcium scoring. Participants will have one neck ultrasound visit and their results will be compared to their heart CT calcium score results to see how well they align. The aim is to determine if ultrasound could safely reduce reliance on CT-based testing in low-to-intermediate risk patients. This could help guide diagnostic pathways and resource use for suspected coronary disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \> 18 years old
2. Symptomatic patients with suspected CCS, judged by the clinician to require CTCA with CAC scoring, for the diagnosis of CAD
3. Have a RF-CL 5-15%, as calculated using ESC guidelines
4. Able to give informed consent to participate in the study and its follow up

Exclusion Criteria:

1. Age \<18 years old
2. Diagnosed ACS requiring hospitalization or urgent or emergent testing
3. Known CAD with prior MI, PCI, CABG or any angiographic evidence of CAD (≥50% lesion in a major epicardial vessel)
4. History of previous stroke or known peripheral vascular disease
5. Known significant cardiac congenital abnormalities
6. Pregnancy
7. Life expectancy \< 1 years
8. Unable to provide written informed consent

Where it's running

• Northwick Park Hospital
  Harrow, United Kingdom Recruiting

Study contacts

• Study coordinator: Emma Howard
• Email: lnwh-tr.cardiacresearch@nhs.net
• Phone: +4402088692548

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.