Condition

Percutaneous Coronary Intervention (PCI) clinical trials and research

• 23Clinical trials
• 3NIH research projects
• 16Countries

Newest Percutaneous Coronary Intervention (PCI) clinical trials

All recruiting trials (23)

• Trends and risk factors for adverse events after primary PCI in AMI patients over 20 years

  This study looks at real-world AMI patients who had a primary PCI to see how often serious events happen during a 2-year follow-up and what factors predict them.

  Recruiting Shanghai Zhongshan Hospital · Shanghai · NCT07833995

• Cold-region exposure and heart remodeling after PCI

  This study tests whether long-term cold exposure before PCI is linked to worse heart remodeling and outcomes in people with coronary artery disease.

  Recruiting Chinese PLA General Hospital · Beijing, Please Select An Option Below · NCT07773870

• Coronary Extension Catheter in PCI for CAD patients

  This study tests whether using a coronary extension catheter during PCI helps adults with coronary artery disease.

  Recruiting BrosMed Medical Co., Ltd · Beijing · NCT07742345

• BRIDGE: Embedding consumer mHealth tools into cardiac rehab

  This study tests whether adding a mobile health tool to standard center-based cardiac rehab helps heart patients stay active and follow healthy habits.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07741396

• Revascularization of Calcified Coronary Arteries

  This study tests whether measuring blood flow and pressure before and after ballooning or stenting of calcified coronary arteries can help predict how well the procedure will work for adults with heart disease.

  Recruiting Aalborg University Hospital · Aalborg · NCT07724184

• Serpentine vs Hydrophilic Guidewire for tricky radial arteries

  This study tests whether the Serpentine technique can improve success and safety when performing coronary procedures through a radial artery with loops or tortuosity.

  Recruiting University Hospital of Patras · Pátrai · NCT07707427

• Advanced invasive diagnosis for post-PCI angina in patients referred for coronary angiography

  This study tests a specialized invasive approach to find the cause of angina in people who previously had PCI and are now referred for coronary angiography.

  Recruiting at 5 sites Fundacion Investigacion Interhospitalaria Cardiovascular · Leganés, Madrid and 4 other locations · NCT07638137

• Transcutaneous auricular vagus nerve stimulation for depression after heart procedures

  This study tests whether at-home taVNS can help reduce depressive symptoms in adults 18–80 who recently had PCI for ACS.

  Recruiting Tang-Du Hospital · Xi'an, Shaanxi · NCT07454070

• Best way to fix under‑expanded coronary stents in resistant blockages

  This compares intravascular lithotripsy (IVL) with high‑pressure or specialty balloons to see if IVL opens under‑expanded coronary stents better in people with in‑stent restenosis.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, Auvergne and 1 other locations · NCT07316504

• Outcomes after PCI using the Protégé paclitaxel drug-coated balloon.

  This registry will collect real-world data to see if the Protégé paclitaxel drug-coated balloon works well and is safe for adults having PCI for coronary artery disease or acute coronary syndrome.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07231835

• Very short DAPT after PCI in older adults

  This trial tests whether stopping aspirin after 7 days of dual antiplatelet therapy is as safe and effective as continuing DAPT for 3 to 12 months in people 65 and older who had a PCI with drug-eluting stents.

  Recruiting Phase 3 University Hospital, Caen · Caen · NCT07164859

• Drug-coated balloon with bail-out bioresorbable scaffold versus scaffold alone for new coronary artery blockages

  This test sees if using a drug-coated balloon with bail-out bioresorbable scaffold works as well as using a bioresorbable scaffold alone for adults 18–68 getting PCI for new coronary artery blockages, including certain heart attacks and unstable angina.

  Recruiting Ceric Sàrl · Tallinn · NCT07038408

• Switching from clopidogrel to low-dose prasugrel after PCI in people at high bleeding and ischemic risk

  We will test whether switching adults who had PCI and are at both high bleeding and ischemic risk from standard-dose clopidogrel to low-dose prasugrel lowers platelet reactivity compared with staying on clopidogrel.

  Recruiting Phase 4 University of Florida · Jacksonville, Florida · NCT07025148

• Using Medipixel XA technology for heart artery procedures

  This study is testing a new technology called Medipixel XA to see if it can make heart artery procedures safer and more effective for people with coronary artery disease.

  Recruiting at 6 sites CHA University · Gwangmyeong, Gyeonggi-do and 5 other locations · NCT06985693

• Comparing two techniques for treating complex coronary bifurcation lesions

  This study is testing two different ways to treat complex heart artery blockages to see which one helps patients feel better and have fewer heart problems after the procedure.

  Recruiting at 2 sites Istanbul Mehmet Akif Ersoy Educational and Training Hospital · Istanbul and 1 other locations · NCT06931574

• Optimal stent deployment strategy for thinner-strut bioresorbable scaffolds guided by intracoronary imaging

  This study tests whether using a thinner-strut bioresorbable scaffold with OCT/IVUS imaging guidance improves outcomes in adults with stable CAD undergoing PCI.

  Recruiting Albert Schweitzer Ziekenhuis, Netherlands · Dordrecht · NCT06919562

• Reduced-dose prasugrel alone after PCI in acute and chronic coronary syndrome

  This test tries whether taking a low 5 mg daily dose of prasugrel alone after a successful PCI can prevent clots while lowering bleeding risk in people with acute or chronic coronary syndromes.

  Recruiting Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06916520

• 3D Stent test to detect stent under-expansion during PCI

  This will test whether 3D Stent can detect stent under-expansion as well as intravascular imaging in people having PCI for coronary artery disease.

  Recruiting CoreAalst BV · Aalst and 3 other locations · NCT06898021

• Effects of aerobic exercise on heart function in patients with heart disease

  This study tests whether different types of aerobic exercise can improve heart function in patients with heart disease who have recently had treatment.

  Recruiting at 2 sites Instituto de Investigación Sanitaria y Biomédica de Alicante · Alicante, Alicante and 1 other locations · NCT06788275

• Comparing orbital atherectomy and intravascular lithotripsy for calcified coronary nodules

  This pilot trial will see if orbital atherectomy or intravascular lithotripsy better prepares OCT-identified calcified coronary nodules for stent placement in adults with coronary artery disease.

  Recruiting at 6 sites Spanish Society of Cardiology · Alicante, Alicante and 5 other locations · NCT06736665

• Hybrid PCI using a magnesium bioresorbable scaffold plus drug-coated balloons versus drug-eluting stents for long, diffuse coronary artery disease

  It will test whether combining a magnesium bioresorbable scaffold with paclitaxel drug-coated balloons works as well as newer drug-eluting stents for people with long or diffuse coronary artery blockages who need PCI.

  Recruiting at 4 sites University Hospital, Geneva · Geneva, Canton of Geneva and 3 other locations · NCT06710210

• Comparing two types of drug-eluting stents for heart procedures

  This study is testing whether a new type of heart stent with a thinner design works better and is safer than a traditional stent for patients with blocked arteries.

  Recruiting at 3 sites Odense University Hospital · Aalborg and 2 other locations · NCT06692140

• Using P2Y12 inhibitors alone for patients with atrial fibrillation getting stents

  This study is testing if using just one type of blood thinner for a month, followed by a different one, is safer and just as effective for people with atrial fibrillation who are getting heart stents, compared to the usual combination of three blood thinners.

  Recruiting at 5 sites Phase 4 Insel Gruppe AG, University Hospital Bern · Hasselt and 14 other locations · NCT05955365

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Metasurface Optical Guidewire to Treat Coronary Artery Calcification

  A new optical guidewire technology aims to improve safety and effectiveness of coronary interventions in people with calcified arteries.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11468164

• Using electronic health records to identify complications after heart procedures

  This study is working on a smart way to spot problems that can happen after a common heart procedure called PCI, using computer programs to look at health records, so that doctors can better keep you safe and provide the best care possible.

  NIH research Yale University · New Haven, United States · NIH-11001500

• New optical guidewires for treating blocked coronary arteries

  This study is testing new, flexible guidewires that use special light technology to help doctors treat blocked arteries in patients with hard, calcified arteries, making heart procedures safer and more effective.

  NIH research University of California-Irvine · Irvine, United States · NIH-10865571

Related topics

Quick answers

How many Percutaneous Coronary Intervention (PCI) clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in Spain (5 trials), France (4 trials), China (4 trials), Netherlands (4 trials), Belgium (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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