Assessing non-significant coronary artery disease lesions using advanced imaging techniques
Evaluation of the Ability of CTFFR to Determine Non-significant Lesions of Coronary Disease Based on MACE in One-year Follow-up of Patients (Seeing Beyond the Stenosis: CTFFR and MACE in a One-Year Follow-Up)
This study is trying to see if advanced imaging techniques can help doctors better understand and manage patients with heart artery blockages that might not be serious.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Shiraz University of Medical Sciences Academic / other |
| Locations | 1 site (Shiraz, Fars) |
| Trial ID | NCT06979427 on ClinicalTrials.gov |
What this trial studies
This prospective cohort study involves 250 patients with suspected or known chronic coronary syndrome who have at least one intermediate coronary lesion. Participants undergo coronary computed tomography angiography (CCTA) and fractional flow reserve (FFR) testing to evaluate the significance of their lesions. Data on patient demographics and lesion characteristics are collected, and patients are monitored for major adverse cardiovascular events (MACE) over one year. The study aims to improve the understanding of non-significant coronary artery disease lesions and their management.
Who should consider this trial
Good fit: Ideal candidates are patients with suspected or known chronic coronary syndrome and at least one intermediate coronary lesion (50-70% stenosis).
Not a fit: Patients who have undergone previous coronary artery bypass graft surgery or have significant renal impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better identification and management of patients with non-significant coronary artery disease, potentially reducing unnecessary interventions.
How similar studies have performed: Similar studies have shown promise in using advanced imaging techniques to assess coronary artery disease, indicating that this approach is supported by prior research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients were enrolled if they had at least one intermediate coronary lesion (classified as 50-70% diameter stenosis on visual judgment) on CCTA and then underwent FFR testing Exclusion Criteria: * Patients having past coronary artery bypass graft surgery (CABG) * previous PCI in the target vascular * significant renal impairment define with eGFR \< 30 mL/min/1.73 m² * contrast allergy * poor image quality that prevented appropriate CCTA or CT-FFR analysis
Where this trial is running
Shiraz, Fars
- Professor Kojuri Cardiology Clinic — Shiraz, Fars, Iran (Recruiting)
Study contacts
- Study coordinator: javad UOM kojuri
- Email: kojurij@yahoo.com
- Phone: 09171115083
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.