Measuring Tryptase Levels in Patients with Stable Coronary Artery Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to measure serum tryptase levels in patients with stable coronary artery disease (CAD) and correlate these levels with the severity of their condition. It will investigate the potential of tryptase as a prognostic biomarker for predicting future cardiovascular events, particularly the transition from chronic coronary syndrome (CCS) to acute coronary syndrome (ACS). The study focuses on the role of mast cell activation in plaque instability, which may contribute to sudden cardiovascular events in patients with CCS. By analyzing the relationship between tryptase levels and cardiovascular health, the study seeks to enhance understanding of CAD progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female subjects aged 18 - 85 years old.
* Clinical symptoms of angina which are classified based on the Canadian Cardiovascular Score (CCS score)
* Positive SPECT scan for myocardial ischemia

Exclusion Criteria:

* Acute Coronary Syndrome 4 weeks before the coronary catheterization
* Percutaneous Coronary Angioplasty
* Coronary Artery Bypass Graft
* Active symptoms of allergy (asthma, urticaria)
* Mastocytosis
* Hypereosinophilia
* Autoimmune disease
* Cancer
* Kidney failure
* Myelodysplastic Syndrome
* Denial of signing informed consent

Where it's running

• 417 Military Hospital NIMTS
  Athens, Attica, Greece Recruiting
• Larisa University Hospital
  Larissa, Thessaly, Greece Recruiting

Study contacts

• Study coordinator: Fotios Skoufis, MD Medicine
• Email: fskoufis@hotmail.com
• Phone: +306981088650

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.