Aspirin 50 mg vs 100 mg with a P2Y12 inhibitor after PCI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, open-label, randomized non-inferiority study in China compares low-dose (50 mg) versus standard-dose (100 mg) enteric-coated aspirin, each plus a P2Y12 inhibitor, in adults who have recently had PCI and will continue DAPT for at least 12 months. Participants are randomized 1:1 and followed for 12 months, with MACCE and safety outcomes adjudicated by an independent committee. The choice of P2Y12 inhibitor (ticagrelor or clopidogrel) is per physician discretion. An independent data monitoring committee oversees safety, and events are defined by standardized international criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 to 85 years at the time of screening
* Diagnosed with acute coronary syndrome (ACS) or chronic coronary syndrome (CCS)
* Has undergone successful percutaneous coronary intervention (PCI) with stent implantation
* Planned to receive at least 12 months of dual antiplatelet therapy (DAPT) with aspirin plus a P2Y12 inhibitor after PCI
* Able to provide written informed consent and comply with study follow-up requirements

Exclusion Criteria:

* Known hypersensitivity or contraindication to aspirin, P2Y12 inhibitors, or related excipients
* High bleeding risk: history of intracranial hemorrhage, gastrointestinal bleeding within 6 months, active bleeding diathesis, or coagulopathy
* Severe hepatic dysfunction (Child-Pugh class C) or severe renal impairment (eGFR \< 30 mL/min/1.73 m²)
* Ischemic or hemorrhagic stroke within 3 months before enrollment
* Pregnant or lactating women; women of childbearing potential unwilling to use effective contraception
* Life expectancy \< 12 months due to other severe comorbidities such as advanced malignancy
* Participation in another interventional clinical trial within 30 days before screening
* Any other condition judged by the investigator to make the patient unsuitable for the study

Where it's running

• First Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: Qian Tong, MD
• Email: tongqian187@aliyun.com
• Phone: '+86-13074337289'

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Long-term P2Y12 inhibitor monotherapy and blood clotting after angioplasty

  This trial will test whether specific P2Y12 drugs and reduced doses given alone keep platelet activity in a safe therapeutic range for people who completed initial dual antiplatelet therapy after PCI.

  Recruiting Phase 3 Cardiocentro Ticino · Lugano, Ch/ti · NCT07582835

• See if stopping long-term aspirin is as good as continuing it in older adults with stable ischemic heart disease

  In adults 65 and older with stable ischemic heart disease, this trial tests whether stopping daily low-dose aspirin is not worse than continuing it.

  Recruiting at 2 sites Phase 4 Odense University Hospital · Copenhagen and 1 other locations · NCT07795398

• Can CZT-SPECT/CT quantify myocardial tracer uptake to match PET measurements in coronary artery disease?

  This study tests whether CZT-SPECT/CT can quantify heart blood flow at rest and stress and see if the results align with PET measurements for people with coronary artery disease.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans, Loiret · NCT07708805

• What affects bleeding control and how long you need to lie flat after femoral arterial sheath removal

  We will see if patient and procedure factors can predict how long ICU patients need compression and bed rest after femoral arterial sheath removal to prevent bleeding and hematoma.

  Recruiting National Taiwan University Hospital · Taipei · NCT07469397

• Doctors' and patients' preferences for PCI implantation devices

  This questionnaire tests what patients who have had PCI and the doctors who treat them prefer between drug-eluting stents and drug-coated balloons.

  Recruiting Xijing Hospital · Xi'an, Shannxi · NCT07378163

• How patients and doctors value different outcomes after coronary stent procedures

  This project asks patients who had a coronary stent (PCI) and the doctors who treat them to rate how important different possible outcomes are to see if their priorities match.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07378137

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.