Healthy Nordic diet's effects on heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of a Healthy Nordic diet on atherosclerosis in patients with coronary heart disease (CHD). A total of 150 participants will be randomized to either follow a Healthy Nordic diet or a usual care diet for 18 months. The study will assess changes in plaque volume, coronary artery calcification, and plaque inflammation using advanced imaging techniques, while also examining the gut microbiota's role in these changes. Additionally, metabolic phenotyping will be used to predict dietary response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women
* Diagnosis with MI from 2 weeks after diagnosis and with maximum 6 months after diagnosis
* Diagnosis with CCS (e.g. stable angina pectoris)
* Ages 50 to 80 years
* BMI 25-40.

Exclusion Criteria:

* Severe heart failure (NYHA classes III, IV)
* Alcohol intake \>20g/day
* Unwillingness to follow a new prescribed diet for 18 months
* Other diseases implying a short estimated life expectancy (e.g. severe malignant or kidney or liver disease, as judged by consenting physician).

Where it's running

• Cardiology clinic, Uppsala university hospital
  Uppsala, Sweden Recruiting

Study contacts

• Principal investigator: Ulf Risérus, MMED, PHD — Uppsala University
• Study coordinator: Emil Hagström, MD, PHD
• Email: emil.hagstrom@ucr.uu.se
• Phone: 46184710000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.