Healthy Nordic diet's effects on heart disease
A Healthy Nordic Diet to Reduce the Progression of Atherosclerosis in Individuals with Coronary Heart Disease: a Secondary Prevention Trial
This study is testing if following a Healthy Nordic diet can help people with coronary heart disease improve their heart health over 18 months.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | Uppsala University Academic / other |
| Locations | 1 site (Uppsala) |
| Trial ID | NCT06701968 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of a Healthy Nordic diet on atherosclerosis in patients with coronary heart disease (CHD). A total of 150 participants will be randomized to either follow a Healthy Nordic diet or a usual care diet for 18 months. The study will assess changes in plaque volume, coronary artery calcification, and plaque inflammation using advanced imaging techniques, while also examining the gut microbiota's role in these changes. Additionally, metabolic phenotyping will be used to predict dietary response.
Who should consider this trial
Good fit: Ideal candidates are men and women aged 50 to 80 with a recent myocardial infarction or chronic coronary syndrome and a BMI between 25 and 40.
Not a fit: Patients with severe heart failure, significant alcohol consumption, or other serious health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a dietary intervention that significantly reduces atherosclerosis and improves heart health in patients with coronary heart disease.
How similar studies have performed: Previous studies have shown that healthy Nordic diets can reduce cardiovascular risk factors, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women * Diagnosis with MI from 2 weeks after diagnosis and with maximum 6 months after diagnosis * Diagnosis with CCS (e.g. stable angina pectoris) * Ages 50 to 80 years * BMI 25-40. Exclusion Criteria: * Severe heart failure (NYHA classes III, IV) * Alcohol intake \>20g/day * Unwillingness to follow a new prescribed diet for 18 months * Other diseases implying a short estimated life expectancy (e.g. severe malignant or kidney or liver disease, as judged by consenting physician).
Where this trial is running
Uppsala
- Cardiology clinic, Uppsala university hospital — Uppsala, Sweden (Recruiting)
Study contacts
- Principal investigator: Ulf Risérus, MMED, PHD — Uppsala University
- Study coordinator: Emil Hagström, MD, PHD
- Email: emil.hagstrom@ucr.uu.se
- Phone: 46184710000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.