Plasma NT‑proBNP and the extent of coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators prospectively measured plasma NT‑proBNP in consecutive adults referred for elective diagnostic coronary angiography over a two‑year period. They compared NT‑proBNP levels with the presence, extent, and severity of coronary stenoses found on angiography. Patients with conditions known to raise NT‑proBNP—heart failure, severe valvular disease, atrial fibrillation, severe CKD (eGFR <30 mL/min), prior CABG, or age over 80—were excluded to reduce confounding. NT‑proBNP was measured during hospitalization before or around the time of angiography to link biomarker levels with angiographic burden.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patient referred for elective coronary angiography due to suspected CAD.
* NT-proBNP measurement during hospitalization

Exclusion Criteria:

* heart failure
* severe valvular disease
* atrial fibrillation
* severe chronic kidney disease (eGFR \< 30 mL/min)
* prior coronary artery bypass grafting
* age over 80 years

Where it's running

• IRCCS San Raffaele Hospital
  Milan, Italy, Italy Recruiting
• IRCCS San Raffaele Hospital
  Milan, Italy, Italy Completed

Study contacts

• Study coordinator: Carlo Gaspardone
• Email: gaspardone.carlo@hsr.it
• Phone: +393389920314

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.