Hemp-derived CBD for helping people reduce high-potency cannabis use
Official title: Hemp-derived Cannabidiol for the treatment of cannabis use disorder in concentrate users: A double-blind placebo-controlled randomized trial
Funded at University of Colorado · NIH-11361074 · Data updated 2026-11-12
A clinical trial tests whether hemp-derived CBD can help adults reduce cannabis use and related withdrawal and mood symptoms when using high-potency cannabis concentrates.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $694,985 |
| NIH project number | 5R01DA059234-04 |
| Project ID | NIH-11361074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ who use cannabis concentrates and are motivated to reduce or abstain.
✕Less likely to help
Individuals not seeking to reduce concentrate use or those with contraindications to CBD exposure may not benefit.
What this research studies
This study will enroll adults 21 and older who are using cannabis concentrates and trying to abstain. It compares hemp-derived CBD products (full spectrum with ~0.3% THC and broad spectrum with 0% THC) against a placebo in a double-blind setup over several weeks. Researchers will monitor cannabis use, withdrawal, mood, and safety to see if CBD helps decrease use and improves affective symptoms. The trial uses a randomized, controlled design to determine if this available, consumer-friendly CBD can support reduction of high-potency cannabis use in a real-world setting.
Why it matters
Potential benefit: If successful, participants may experience reduced cannabis use and improved withdrawal and mood symptoms.
How similar studies have gone: Past studies with CBD show promise for reducing cannabis use, but data in hemp-derived forms and high-potency concentrates are limited and exploratory.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Bidwell, L. Cinnamon — University of Colorado
- Study coordinator: Bidwell, L. Cinnamon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.