NIH-funded research R21 grant

Brain Stimulation and Training for Cannabis Use Disorder

Official title: Examination of potential effectiveness of transcranial direct current stimulation (TDCS) paired with reappraisal training for Cannabis Use Disorder

Funded at Yale University · NIH-11123332 · Data updated 2026-11-12

This project explores if a gentle brain stimulation combined with training can help people reduce their cannabis use.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionYale University
NIH-funded
Lab location1 site (New Haven, United States)
Project startJuly 1, 2024
Project endJune 30, 2026
Funding year2025
Award (this year)$209,375
NIH project number5R21DA058713-02
Project IDNIH-11123332 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are individuals seeking to reduce their cannabis use who are willing to participate in brain stimulation and reappraisal training sessions.

Less likely to help

Patients not seeking to reduce cannabis use or those with contraindications for TDCS may not receive benefit from this specific approach.

What this research studies

This project aims to find better ways to help people with Cannabis Use Disorder (CUD) by combining a gentle brain stimulation called transcranial direct current stimulation (TDCS) with a type of mental training called reappraisal. TDCS targets a specific brain area to help improve self-regulation skills, while reappraisal training teaches individuals how to manage cravings and emotional responses. Researchers will recruit sixty participants to receive either real or sham TDCS alongside reappraisal training over five weekly sessions. The goal is to see if this combination can enhance emotional regulation, leading to a reduction in cannabis use and changes in brain activity related to self-control.

Why it matters

Potential benefit: If successful, this approach could offer a new and effective way to help individuals manage and reduce their cannabis use.

How similar studies have gone: Previous work by the research team on internet gaming disorder suggests that enhancing regulation skills with TDCS may be helpful for addictive behaviors.

Where this research is happening

  • Yale University
    New Haven, United States
    Active

Researchers

  • Principal investigator: Potenza, Marc N — Yale University
  • Study coordinator: Potenza, Marc N

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.