Exploring a new treatment for Cannabis Use Disorder
Official title: Advancement of AEF0117 as a potential treatment for Cannabis Use Disorder: Preclinical toxicity and Clinical pharmacokinetic studies
Funded at New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-10668477 · Data updated 2026-11-12
This study is testing a new medication called AEF0117 to see if it can help people who want to reduce their cannabis use, and it includes both animal tests and trials with volunteers to make sure it's safe and works well.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,253,950 |
| NIH project number | 5U01DA053832-03 |
| Project ID | NIH-10668477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Cannabis Use Disorder who are seeking treatment options.
✕Less likely to help
Patients who do not have Cannabis Use Disorder or those who are not interested in pharmacological treatment may not benefit from this research.
What this research studies
This research focuses on AEF0117, a novel medication aimed at treating Cannabis Use Disorder (CUD). It involves conducting safety and pharmacokinetic studies to evaluate how the drug behaves in the body and its potential effectiveness in reducing cannabis use. The research includes both animal studies and trials with human volunteers to ensure the medication is safe and effective before larger clinical trials. Patients may benefit from a new treatment option that could help manage their cannabis use.
Why it matters
Potential benefit: If successful, this research could provide a new, effective medication for individuals struggling with Cannabis Use Disorder.
How similar studies have gone: Previous studies have shown promising results with similar medications aimed at treating substance use disorders, indicating potential for success with this approach.
Where this research is happening
-
New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
New York, United States Active
Researchers
- Principal investigator: Levin, Frances Rudnick — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Levin, Frances Rudnick
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-
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A big study will look at how cannabis use and cannabis use disorder affect older people with HIV, including how it relates to aging problems and HIV treatment success.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.