Using hemp-derived cannabidiol to help people reduce cannabis use
Official title: Hemp-derived Cannabidiol for the treatment of cannabis use disorder in concentrate users: A double-blind placebo-controlled randomized trial
Funded at University of Colorado · NIH-10925377 · Data updated 2026-11-12
This study is looking at how well hemp-derived CBD can help people who are having trouble with cannabis use, especially those using strong cannabis products, by comparing two types of CBD—one with a little THC and one without—to see which one helps reduce withdrawal symptoms and cannabis use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $725,910 |
| NIH project number | 5R01DA059234-02 |
| Project ID | NIH-10925377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing cannabis use disorder, particularly those using high-potency concentrates.
✕Less likely to help
Patients who do not use cannabis or who are not experiencing issues related to cannabis use disorder may not benefit from this research.
What this research studies
This research investigates the effectiveness of hemp-derived cannabidiol (CBD) in treating cannabis use disorder, particularly among users of high-potency cannabis concentrates. The study will compare the effects of two forms of CBD—one with a small amount of THC and one without—on withdrawal symptoms and overall cannabis use. Participants will be randomly assigned to receive either CBD or a placebo, and their progress will be monitored over time to assess changes in cannabis consumption and related symptoms. This approach aims to provide a more accessible treatment option for individuals struggling with cannabis use disorder.
Why it matters
Potential benefit: If successful, this research could offer a new, effective treatment for individuals seeking to reduce or quit cannabis use.
How similar studies have gone: Previous studies have shown promising results using synthetic CBD for cannabis use disorder, but this research is novel as it focuses on widely available hemp-derived CBD.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Bidwell, L. Cinnamon — University of Colorado
- Study coordinator: Bidwell, L. Cinnamon
Related research
Other NIH-funded projects on the same topics.
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Hemp-derived CBD for reducing cannabis use in high-THC concentrate users
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A big study will look at how cannabis use and cannabis use disorder affect older people with HIV, including how it relates to aging problems and HIV treatment success.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.