IgG glycosylation and endothelial FcγRIIB: understanding RA-related heart and blood vessel disease
Official title: Novel Role of IgG Glycosylation and Endothelial FcγRIIB in Cardiovascular Complications in Rheumatoid Arthritis
Funded at Ut Southwestern Medical Center · NIH-11448488 · Data updated 2026-11-12
This project looks at how rheumatoid arthritis affects blood vessels and clotting, with the goal of uncovering new ways to prevent heart and stroke risk for people with RA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $749,229 |
| NIH project number | 1R01HL189083-01 |
| Project ID | NIH-11448488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with rheumatoid arthritis or people at risk for RA-related cardiovascular disease who are eligible for future translational studies or trials.
✕Less likely to help
Individuals without RA or without cardiovascular involvement related to RA are unlikely to benefit from this research.
What this research studies
People with rheumatoid arthritis face higher chances of heart disease, stroke, and blood clots. The research team is studying how immune signals and blood vessel cells interact to drive these risks, using a mouse model that mimics arthritis-related vascular problems. By examining endothelial function and related pathways, they aim to identify targets that could reduce cardiovascular events in RA patients. The work integrates human disease context with animal studies to illuminate mechanisms that could guide future therapies.
Why it matters
Potential benefit: If successful, the study could reveal new targets to lower cardiovascular risk in people with rheumatoid arthritis and inform strategies to prevent heart attacks and strokes.
How similar studies have gone: Prior work has linked endothelial dysfunction to RA-associated cardiovascular risk, supporting the plausibility of this approach but mechanistic details remain to be defined.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Mineo, Chieko — Ut Southwestern Medical Center
- Study coordinator: Mineo, Chieko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.